CasNo.41100-52-1,Memantine hydrochloride 99%,(41100-52-1) Suppliers

1 Metric Ton	Negotiable

Min.Order :1 Metric Ton
Purity: 99%
Payment Terms : T/T,

Keywords

Memantine hydrochloride Memantine HCl Memantine

Quick Details

Appearance:white power
Application:Pharma;Industry;Agricultural;chemical reaserch
PackAge:as your requirement
ProductionCapacity:1000|Metric Ton|Month
Storage:Keep it in dry,shady and cool place
Transportation:SEA OR AIR

Superiority:

1,we produce and sell good chemicals around the world.

2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.

3,our staff consists of highly qualified individuals with bsc, msc and ph.d degrees in chemistry, as well as excellent carbohydrates,nucleosides, small molecules and rare chemicals.

4,imaginechem's chemists are skilled at performing complex, multi-step syntheses and solving difficult chemistry-related problems. because of our better, concentracted size and low overheads, we are able to offer prompt quotations, very competitive prices, high quality products and fast delivery.

5,all chemicals are typically >97% for building blocks, the structure and purity is confirmed by nmr and lc-ms. intermediates and final products are analyzed by gc, hplc, ir, nmr, ms, elemental analysis, atom-absorpting analysis and crystallographical methods.

6,Customers-oriented strategy, exclusive supply chain management, professional R&D team, experienced production workers, energetic sales team enable us to offer best service andgood-value products to all of our customers and gradually reach our final goals: becoming global leading supplier for portable products and solutions.

Details:

Hydrochloric acid dollars just was developed by the German Merz company alzheimer's treatments, is a kind of new type, low to moderate affinity, voltage dependence, non-competitive N - methyl - D - aspartate (NMDA) receptor antagonist medicine, non-competitive block NMDA receptor, reduce NMDA glutamate receptor euphoria, prevent apoptosis, improve memory, is a new generation of drugs to improve cognitive function.

In February 2002, the European patent medicines commission (CPMP) approved its use for the treatment of moderate and severe alzheimer's disease, and it was put on the market in Germany in August of the same year. On October 17, 2003, it was approved by the us food and drug administration (FDA) for the treatment of moderate and severe alzheimer's disease. Further studies have shown that memantine hydrochloride is also effective in patients with mild and moderate alzheimer's disease.

Alzheimer's disease (AD), also known as senile dementia, is one of the common diseases of the elderly, mainly manifested as memory impairment and cognitive impairment, is a progressive neurodegenerative disease. Currently, cholinesterase inhibitors (donepezil, carbaratine, galantamine) and mycin hydrochloride are approved for the treatment of alzheimer's disease.

Hydrochloric acid dollars just was developed by the German Merz company alzheimer's treatments, is a kind of new type, low to moderate affinity, voltage dependence, non-competitive N - methyl - D - aspartate (NMDA) receptor antagonist medicine, non-competitive block NMDA receptor, reduce NMDA glutamate receptor euphoria, prevent apoptosis, improve memory, is a new generation of drugs to improve cognitive function.

In February 2002, the European patent medicines commission (CPMP) approved its use for the treatment of moderate and severe alzheimer's disease, and it was put on the market in Germany in August of the same year. On October 17, 2003, it was approved by the us food and drug administration (FDA) for the treatment of moderate and severe alzheimer's disease. Further studies have shown that memantine hydrochloride is also effective in patients with mild and moderate alzheimer's disease.

1. Combined use with huperzine a: huperzine a is a drug extracted from huperzine, a traditional Chinese medicine, and it is a reversible competitive cholinesterase inhibitor. Meminguon has different binding abilities to different glutamate receptor subtypes or ion channels, reducing the excitotoxic effects of glutamate, thus treating AD. AD patients not only have a variety of neurotransmitter changes, but also have abnormal postsynaptic receptors. Therefore, the combination of cholinesterase inhibitors and glutamate receptor inhibitors can play a synergistic role.

2. Combination with donepezil: as the second-generation cholinesterase inhibitor, donepezil has high selectivity of cholinesterase in the central nervous system, long half-life and lower toxicity than huperzine a. Donepezil and huperzine a act on different nerve conduction systems, and when they are used together, a synergistic effect can be produced to enhance the efficacy. Although the specific mechanism of action has not been discovered, it has been proved that patients with moderate or severe AD who are treated with memantine hydrochloride in combination with other drugs will have better therapeutic effects.

3. Combined use with nimodipine: nimodipine, a Ca2+ antagonist of dihydropyridine, can act on nerve cells, cerebrovascular cells and glial cells of the central nervous system, and can significantly expand the diameter of cerebral vessels and meninges, thus delaying the cognitive decline of patients to a certain extent. When nimodipine is combined with memantine hydrochloride, its different pharmacological action links and mechanisms may complement each other to produce better therapeutic effect.

4. With the combined use of ginkgo biloba on: the main ingredients of flavonoids from ginkgo biloba leaves and tomato in lipid compounds, antithrombotic, anticoagulation, antiplatelet aggregation, antioxidant and lipid effect, improve the permeability of blood vessel walls and reduce the brain injury, for the brain microvascular smooth muscle cells have a protective effect, the protection of "vascular damage" has obvious effect [14]. Vascular factors play an increasingly important role in the pathogenesis of AD. A large number of epidemiological, clinical and basic studies have shown that many risk factors related to vascular factors or hemodynamics can increase the risk of AD. Therefore, memangang hydrochloride, which ACTS on NMDA receptors, can play a synergistic role in combination with ginkgo biloba.

The descriptions, properties, and synthesis methods of memantine hydrochloride are compiled by the Chemicalbook. Currently, cholinesterase inhibitors (donepezil, carbaratine, galantamine) and megamind hydrochloride are approved for the treatment of alzheimer's disease.