High quality 2-Pyridinecarboxamide,4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl

Sorafenib (CAS 284461-73-0) is one anti-cancer drug. Sorafenib (CAS 284461-73-0) can be used in the treatment of primary kidney cancer, and hepatocellular carcinoma. Sorafenib (CAS 284461-73-0) has been formulated into finished dosage forms and marketed under the brand name Nexavar by Bayer and Onyx Pharmaceuticals.
Sorafenib (CAS 284461-73-0) is one API approved by EU/FDA and other authorities for the treatment of anti-cancer.

Sorafenib is a RAF kinase inhibitor which suppresses ERK phosphorylation. Studies indicate that Sorafenib induces c-Raf phosphorylation $zhanwei$ at both Ser-43 and Ser-259. When combined with vitamin K1 phosphorylation is increased at these serine residues. Sorafenib also induces the phosphorylation of PKA. In addition, Sorafenib induces c-Met phosphorylation at Tyr-1349, which consequently induces PI3K-Akt phosphorylation. Studies determined that Sorafenib inhibits other kinases such as Flk-1 (VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit.

Qingdao Sigma Chemical Co.,Ltd is a global chemical industry manufacturers and suppliers of pharmaceuticals 

and intermediates, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

The aim of Sigma is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

Sigma has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".Sigma has 21 subsidiaries and holding companies.