CasNo.4773-96-0,Mangiferin,(4773-96-0) Suppliers

25 Kilogram	FOB Price: USD 357.7400

Min.Order :25 Kilogram
Purity: 95%
Payment Terms : L/C,T/T,Other

Keywords

2-beta-d-glucopyranosyl-1,3,6,7-tetrahydroxy-9h-xanthen-9-on alpizarin aphloiol

Quick Details

Appearance:white power
Application:Pharma;Industry;Agricultural;chemical reaserch
PackAge:as your requirement
ProductionCapacity:500|Kilogram|Week
Storage:2-8°C，Keep it in dry,shady and cool place
Transportation:SEA OR AIR

Superiority:

1,we produce and sell good chemicals around the world.

2,our success rate is about 95%. this means, if customer order is accepted, the probability that the customer will obtain the ordered substances, is 95%.

3,our staff consists of highly qualified individuals with bsc, msc and ph.d degrees in chemistry, as well as excellent carbohydrates,nucleosides, small molecules and rare chemicals.

4,imaginechem's chemists are skilled at performing complex, multi-step syntheses and solving difficult chemistry-related problems. because of our better, concentracted size and low overheads, we are able to offer prompt quotations, very competitive prices, high quality products and fast delivery.

5,all chemicals are typically >97% for building blocks, the structure and purity is confirmed by nmr and lc-ms. intermediates and final products are analyzed by gc, hplc, ir, nmr, ms, elemental analysis, atom-absorpting analysis and crystallographical methods.

6,Customers-oriented strategy, exclusive supply chain management, professional R&D team, experienced production workers, energetic sales team enable us to offer best service andgood-value products to all of our customers and gradually reach our final goals: becoming global leading supplier for portable products and solutions.

Details:

1. The antioxidant effect due to the particularity of mangiferin structure, intramolecular has multiple phenolic hydroxyl, and phenolic hydroxyl is exactly a important groups of scavenging free radicals and reactive oxygen species. Its mechanism of action of free radicals can be summed up in two aspects: on the one hand, direct effects on free radicals, on the other hand on the iron and copper ions, such as reducing the further and free radicals reaction.

2. The antitumor effect of leukemia associated with cell cycle regulation disorder, and cell cycle regulation between telomerase activity and there is a close relationship. For telomerase and, therefore, the study of the abnormal cell cycle regulation has become a new direction of the study occurrence and treatment of leukemia. The occurrence of leukemia associated with cell cycle regulation disorder, and cell cycle regulation between telomerase activity and there is a close relationship. For telomerase and, therefore, the study of the abnormal cell cycle regulation has become a new direction of the study occurrence and treatment of leukemia.

3. The nerve protective effect with polyphenol structure mangiferin weakened by Ca2 + degree of internal flow and oxidative stress, thus reducing glutamate cause cell death in neurons to protect neurons.

4. The antiviral effect has in vitro against type 1 herpes simplex virus (HSV - I), plaque decrement was 56.8%, the antiviral effect due to its ability to suppress viral replication in the cell.

5. Antifebrile action fever caused by endotoxin experimental animal model has good antipyretic effect, and was positively related with dose, has better protective effect on thermal damage.

6. Analgesic action of acetic acid induced and the pain induced by hot plate test has significant analgesic effect, compared with naloxone hydrochloride, found that mangiferin induced analgesia is not dependent on opioid receptors, its analgesic effect significantly, foreign influence in week nerve slightly.

7. Anti parasitic effect of mangiferin were microscopic cryptosporidium has obvious inhibitory effect. Mangiferin on nematode infection, trichinella spiralis in mice.

8. Oral anti-diabetic effect after mangiferin and glucoside, there were no changes in normal blood glucose level in mice, but can reduce the spontaneous diabetes animal model of KK - Ay mice blood glucose concentration, and the trend of serum insulin levels also have lower. Fruit glycosides and glucoside may show anti-diabetic activity by insulin sensitization.

9. Protect liver cholagogic effect on the liver protective effect, the role of mangiferin in stable lysosome membrane, and to have direct lysosome acid phosphatase activity. Mangiferin has obvious cholagogic effect.

10. The role of the central nervous system of mangiferin has obvious central nervous system stimulant. Mangiferin has a clear brain tissue lipid peroxide effect, reduce lipid peroxide epicuticular neurons damage, in order to ensure the normal function of the neuron.

11. With the function of the respiratory system adrenal glucocorticoid anti-inflammatory effect, can reduce capillary permeability, its anti-inflammatory response rate was 38%. Due to the anti-inflammatory effect of mangiferin, have certain effect on bronchial asthma, characterized by (1) can make the lure out time obviously prolong in the asthma group; (2) relieve asthma degree, tic was lower than that in group asthma incidence; Significantly reduce (3) the emphysema, pulmonary inflammatory cell infiltration in asthma group, significantly less than lung weight/body weight ratio was lower than that in group asthma, and dexamethasone group. At the same time, the mangiferin could reduce the serum NO and alveolar lavage in endothelin 1 (ET 1) level, have certain prevention effect on asthma attacks. Mangiferin and dexamethasone can improve curative effect.