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Baicalin 21967-41-9 99% BY HPLC
Superiority
kono chem is a leading manufacturer and supplier of chemicals in China.
We develop ,produce and distribute high quality pharmaceuticals, intermediates, special chemicals
and other fine chemicals.
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3.mature Technical support
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Company information
Founded in 2012 as a professional international pharmaceutical corporation, headquartered in Xi'an (China), Xi'an Konochemical Co., Ltd, is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.
Annually, more than 3,000 tons of a wide range of herbal extracts and natural active substances are extracted at Xi'an Konochemical Co.,Ltd manufacturing plant near Xi'an, China. These extracts are in compliance with worldwide GMP norms, international Pharmacopoeias, and international regulations.
The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Konochemical. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.
Basic information
Product name: Baicalin
Assay: 98% min
CAS No: 21967-41-9
Plant source; Scutellaria baicalensis Georgi root, S.scordifolia Fisch.(S.galericulata L., Oroxylum indicum(L.), Plantago major L.
Molecular formula: C21H18O11
Molecular weight: 446.35
Specifications: ≥98% HPLC
Characteristics: yellow crystalline, melting point 223~225°C,flavonone glycosides
Main Functions
Baicalin is one of the flavonoids found in the radix of Scutellaria baicalensis that has antioxidant activity.
It scavenges hydroxyl radical, DPPH radical and alkyl radical, and protects cells from oxidative damage. Baicalin also exhibits a variety of biological activities. Its antiinflammatory effect was observed by its inhibition against carrageenan-induced rat paw edema. It has anti-HIV activity. The replication of HIV-1 was inhibited in a dose-dependent manner. One of the mechanisms of inhibition is likely the induction of apoptosis.
Baicalin was found also to inhibit colon aberrant crypts formation induced by azoxymethane and suppressed the growth and metastasis of malignant melanoma in ret-transgenic mice.
Baicalin was extensively researched for utility in a number of therapeutic areas owing to its anti-inflammatory, anti-oxidant, anti-bacterial, and anti-cancer properties. A number of preclinical studies, in vitro work, and mechanistic studies were performed to understand the absorption, distribution, metabolism, and excretion profiles of baicalin. The absorption of baicalin involved several complexities: the restriction to two distant sites; the conversion of baicalin to baicalein; the possible role of transporter(s); and enhanced absorption due to breakdown of conjugates by beta-glucuronidase. Limited distribution data suggest that baicalin reached several sites such as the brain, eye lens, thymus, etc. Hepatobiliary recycling also served as a distribution phase for sustained delivery of baicalin. Metabolism data suggest the rapid conversion of baicalin to baicalein, which was extensively subjected to Phase 2 metabolism, conjugates baicalein glucuronide/sulfate have been identified. Limited excretion data suggest involvement of renal and faecal routes--glucuronide and sulfate conjugates were excreted in urine and faeces (via biliary excretion). The published data on baicalin suggest imminent challenges for developing baicalin and/or during co-administration with other agents. These challenges are absorption related (transporter or changes in the microenvironment), metabolism related (CYP2B6 induction and/or CYP2E1 inhibition), and excretion/efflux related (competitive biliary pathway and/or OATP1B1 transport).
25kg carton drum (32cm*58cm)or 1kg foil bag (10cm*15cm) or by request of clients
Blue plastic drum / Galvanized steel drums/ 200kg Iron drum or 25kg plastic bucket
Founded in 2012 as a professional international pharmaceutical corporation, headquartered in Xi'an (China), Xi'an Konochemical Co., Ltd, is a leading producer of standardized herbal extracts, natural active ingredients and APIs for pharmaceutical, health food and cosmetic industries.
Annually, more than 3,000 tons of a wide range of herbal extracts and natural active substances are extracted at Xi'an Konochemical Co.,Ltd manufacturing plant near Xi'an, China. These extracts are in compliance with worldwide GMP norms, international Pharmacopoeias, and international regulations.
The botanical raw materials are subject to strict selection and inspection, and extracts are manufactured according to methods developed by Konochemical. They include inspections to guarantee a high quality standard from both analytico-chemical and therapeutic points of view, and take into consideration the state of art in different fields: research and development, analyses, processes and machinery, therapeutic applications on a scientific basis.
Kono Chem is headquarted in Xi’ an Shaanxi Province, China, with convenient transportation access, covering an area of 312, 000 square meters, and technicians accounted for 35% of the total employees. Presently, we have two chemical fermentation plant, one test reaction plant, and one Provincial Research and Development Center now. Our well-equipped facilities and excellent quality control throughout production enables us to guarantee customer satisfaction. We insist in innovation and produce high quality products. And our workshops are GMP standard.
We also have strong professional research and development team, talented personnel and completely equipped laboratory for the quality controlling. Various Detection Devices are equipped, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.
From the very beginning, we strictly manage our production according to the international standard like ISO9000,ISO14001, now has received the recogonition from costomers all over the world and has passed the audit by authoritative labs. At present, our products are mainly related to Biopharmaceuticals, Health Care Products, Cosmetic Ingredients, APIs, Intermediates, as well as some custom synthesis products.
Thanks to our EHS management system and high quality control, now 85% of our products are well-selling and appreciated in almost 50 countries all over the world, and established long-term cooperative business relationship with multinational companies such as CIPLA,BIOCON,DSM.
Icy Liu
Tel: +86 29 88770941
Phone:18092125754
Fax:+86 29 81330164
Email: sales7@konochemical .com
Web: www.konochemical.com
Address :11 Daqing Road, Xi’an,Shaanxi 710082, P.R China
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