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5104-49-4 [1,1'-Biphenyl]-4-aceticacid, 2-fluoro-a-methyl [1,1'-Biphenyl]-4-aceticacid, 2-fluoro-a-methyl Price
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escription
Flurbiprofen is a mixture of S(+) and R(-) enantiomers. Flurbiprofen is a cell-permeable, non-steroidal anti-inflammatory
(NSAID) agent that acts as a potent inhibitor of Cox-1 (cyclooxygenase-1) and Cox-2 (cyclooxygenase-2) (IC50 = 5 nM for LPS-
induced Cox in human peripheral blood cells). The S(+) enantiomer is reported to be more potent as a Cox-2 inhibitor than the
R(-) enantiomer. Flurbiprofen suppresses iNOS expression in RAW 264.7 macrophages. It reduces Aβ loads and Congo Red
staining in APP+PS1 transgenic mice.
Specification
Test Item |
Analysis Specification |
Result |
||
Description |
A white or almost white crystalline power |
Conforms |
||
Appearance of solution |
Clear and colourless |
Conforms |
||
Identification |
A,B,C |
Positives |
||
Optical rotation |
-0.1°~ +0.1° |
0° |
||
Melting point |
114~117°C |
114.5~115.6°C |
||
Heavy metals |
NMT 10ppm |
<10ppm |
||
Related substances |
|
|
||
Impurity A |
NMT0.5% |
0.06% |
||
Individual impurity |
NMT0.2% |
0.12% |
||
Total impurity |
NMT1.0% |
0.30% |
||
Loss on drying |
NMT0.5% |
0.28% |
||
Sulphated ash |
NMT0.1% |
0.03% |
||
Assay |
99.0%~100.5% |
99.9% |
CAS NO:30123-17-2
CAS NO:171596-29-5
CAS NO:171596-29-5
CAS NO:171596-29-5
CAS NO:171596-29-5
CAS NO:171596-29-5
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