CasNo.849217-68-1,Cabozantinib,(849217-68-1) Suppliers

0 Metric Ton	Negotiable

Min.Order :0 Metric Ton
Purity: 98% min

Keywords

Cabozantinib XL184; BMS-907351; XL-184; XL184 849217-68-1

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Application:
PackAge:5mg;10mg;50mg;
ProductionCapacity:50-100|Metric Ton|Day
Storage:-20℃
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Superiority:

Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
IC50 value: 0.035 nM [1]
Target: VEGFR2
in vitro: XL184 has weak inhibitory activity against RON and PDGFRβ with IC50 of 124 nM and 234 nM, respectivey, and has low activity against FGFR1 with IC50 of 5.294 μM [1].

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Details:

Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively.
IC50 value: 0.035 nM [1]
Target: VEGFR2
in vitro: XL184 has weak inhibitory activity against RON and PDGFRβ with IC50 of 124 nM and 234 nM, respectivey, and has low activity against FGFR1 with IC50 of 5.294 μM [1].

url：#