851199-59-2 linaclotide linaclotide Price
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Prodcut name |
Linaclotide |
Sequence |
H-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH cyclic(1-6),(2-10),(5-13)-tris(disulfide) |
MOQ |
1MG |
CAS No. |
851199-59-2 |
Appearance |
white powder |
Molecular Formula |
C59H79N15O21S6 |
Molecular Weight |
1526.74 |
Assay |
99% |
Application |
Pharma grade or research purpose |
Packing |
As per your request |
Storage |
Preserve in tight,light-resistant containers in a cool place |
Certification of Analysis
Contents of testing |
Specifications |
||
Appearance |
White or almost white crystalline powder |
||
Identity by HPLC |
The reaction is same with the reference substance |
||
Amino Acid Composition |
±20% of theoretical |
||
Purity (HPLC) |
≥ 98.0% |
||
Related Substance(By HPLC) |
Total Impurities(%)≤ 2.0% Largest Single Impurity(%)≤ 1.0% |
||
Acetate Content(By HPLC) |
≤15% |
||
Water Content(By HPLC) |
≤5.0% |
||
Bacterial Endotoxins |
≤5IU/mg |
Function&Application
Linaclotide is a peptide agonist of the guanylate cyclase 2C. This compound reduces activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements. It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and constipation predominant irritable bowel syndrome (IBS-C) in adults.
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