Details:

Raw Steroid Sarms Powder Stenabolic Sr9011 Bodybuilding/High Quality CAS 1379686-29-9

Product Details:

Product Name: SR9011
CAS: 1379686-29-9 
Appearance: White Powder 
MF: C23H31ClN4O3S
Packaging: Well Disguised Package Or As Your Requirement    
Carrier: EMS,HKEMS,Fedex,DHL,TNT,UPS
Payment: Bitcoin,Money Gram,,Bank Transfer
Delivery: 3-5 Days To Your Detailed Address
Policy: Reship And Discount
Origin: China    
Description:
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. Recommended for use in peroxide cured coatings, sealants, and PCV-based plastisols. Performance properties include: good adhesion, good chemical resistance, good hardness, good heat resistance and high abrasion resistance.
 
Biological Activity:
 
SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790 nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism.

Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

Function:

There's no way to sugarcoat it-though many have tried-maintaining a healthy weight can be difficult. Because it's hard, many have tried "miracle" weight-loss pills and other quick fixes for something that ultimately requires a lifestyle change. Many over-the-counter diet and weigh-loss pills are unregulated and may contain dangerous ingredients. SR9011, however, isn't like appetite suppressants, laxatives, or "fat blockers." And you won't find SR9011 in the ingredient lists of protein powders or exercise supplements.

The difference between SR9009 and other diet pills is in its chemistry. SR9011 is not an appetite
suppressant-as many weight-loss drugs are-and directly works by increasing the metabolic rate of muscle. Your metabolism speeds up and slows down naturally during the day, meaning that sometimes food is used for energy and sometimes it's stored as fat. By re-synching a dysfunctional metabolic clock, SR9011 ensures that food and excess fat are used as energy.

Application:
Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular health and preventing metabolic diseases.

Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure.Treatment of diet-induced obese mice with a SR9011 decreased obesity by reducing fat mass and markedly improving dyslipidaemia and hyperglycaemia.

Usage:
A new compound called SR9011 increases metabolism, fat burning, and muscle growth in the lab.
Scientists at The Scripps Research Institute (TSRI) have successfully tested a drug, called SR9011,
in mice that kickstarts metabolism and results in increased muscle development.
Essentially, it's an exercise regime in a pill.

SR9011 alters the metabolic profile of skeletal muscle in a manner similar to the changes observed [in]
animals that are endurance trained. Basically, the drug sends a signal to the muscle to tell it to modify
its metabolism.

Half of the mice studied showed improved running endurance in terms of both time and distance. What was clearly interesting was that a small, drug-like molecule could increase metabolic rate in skeletal muscle and increase exercise endurance


How to Use
In vitro: SR9011 was used at 5-10 µM concentration in vitro and in cellular assays.

In vivo: IP administration of SR9011 was used at 100 mg/kg once or twice per day for 12-30 days in different mouse models.
Specification:

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