High Quality Monensin

· Introduction:

· Monensin is a polyether antibacterial agent, extracted from fermentation broth of Streptomyces Cinnamonensis. It has the antagonistic activity against fowl coccidiosis. Besides, it can also be used to promote the growth of fattening beef castles and lambs, to increase lactation of the dairy cows.

·   Monensin is a polyether antibiotic of the ionophore group. It exerts an anticoccidial action against Eimeria tenella, E. acervulina, E. mivati, E. brunetti, E. maxima, E. necatrix in chickens, affecting the trophozoites in the first stage of schizogony. Its action is connected with the formation of lipophilic complexes with monovalent ions (sodium and potassium), making the membranes of the coccidial cells permeable to the ions mentioned; hence the active sodium and potassium transport is disturbed. Sodium and chloride are accumulated into the cells of the parasites, drawing water into the sporosoites, causing their swelling and rupture. It hinders the maturing of the schizonts and the development of merozoites. An additional influence is the impeded transport of carbohydrate and the active sporozoite glycolysis provoked by monensin. When orally administered to ruminants (with developed forestomachs), monensin modifies ruminal metabolism, directing it predominantly to the formation of the energetically richer propionic acid (at the expense of the other volatile fatty acids – acetic acid, lactic acid), and to inhibition of protein degradation in the rumen as a result of which feed conversion efficiency is improved and the weight gain is increased. Monensin suppresses also the formation of methane genesis of the ruminants and inhibits its eructation out of the forestomachs which spares energy losses.

· Function:

·   For increased  rate  of  weight  gain; for  the  prevention  and  control of  coccidiosis  due  to Eimeria  bovis  and  Eimeria  zuernii  in  growing  cattle  on  pasture  or  in  dry  lot(stocker  and  feeder cattle  and  dairy  and  beef  replacement  heifers).

· Specification: