151767-02-1 Montelukast Sodium Montelukast Sodium Price
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Molecular Formula: C35H35ClNO3S.Na; C35H35ClNNaO3S
Molecular Weight: 608.17
CAS No.: 151767-02-1
API of anti-asthma drug. Also it is used in the treatment of seasonal transformation
reactions, and PAR.
Appearance: White crystalline powder
Content: 98% by HPLC
Montelukast (trade names Singulair, Montelo-10, and Monteflo and Lukotas in India) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.It is usually administered orally once a day. Montelukast is a CysLT1 antagonist; it blocks the action of leukotriene D4 (and secondary ligands LTC4 and LTE4) on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it. This reduces the bronchoconstriction otherwise caused by the leukotriene and results in less inflammation.
Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific mechanism of action, it does not interact with other asthma medications such as theophylline.
Another leukotriene receptor antagonist is zafirlukast (Accolate), taken twice daily. Zileuton (Zyflo), an asthma drug taken four times per day, blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.
Item |
Specification |
Description |
White or off-white powder |
Assay |
≥99.0% |
Identification |
|
Chemistry |
Must conforms to standard |
Identification (HPLC) |
The retention time of test sample major peak complies to reference standard |
Infrared absorption |
Must complies to reference standard |
Sodium identification |
The solution so obtained responds to the tests for sodium |
pH |
9.0~10.5 |
Impurity |
Not more than 0.5% of any individual impurity is found, the sum of all impurities found is not more than 1.0% |
S-isomer |
NMT 1.0% |
OVI |
Must conforms to standard |
Heavy metals |
NMT 20ppm |
Loss on drying |
NMT 1.0% |
microbe |
|
Bacterium |
NMT 1000 cfu/g |
Mildew |
NMT 100 cfu/g |
Coliform |
NMT 0 cfu/g |
d sulfuric acid.
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