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91374-20-8 2H-Indol-2-one,4-[2-(dipropylamino)ethyl]-1,3-dihydro-, hydrochloride (1:1) 2H-Indol-2-one,4-[2-(dipropylamino)ethyl]-1,3-dihydro-, hydrochloride (1:1) Price
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Ropinirole hydrochloride |
|
Synonyms |
4-(2-Dipropylaminoethyl)-1,3-dihydroindol-2-one hydrochloride |
Brand |
Qindgao Sigma Chemical Co.,Ltd |
Molecular Formula |
C16H24N2O.HCl |
Molecular Weight |
296.84 |
CAS NO |
91374-20-8 |
Ropinirole is a non-ergoline dopamine agonist. It is used in the treatment of Parkinson's disease. Ropinirole is also one of two medications in the United States (U.S.) with a Food and Drug Administration (FDA) approved indication for the treatment of restless legs syndrome (RLS), the other being pramipexole. The discovery of the drug's utility in RLS has been used as a successful example of drug repurposing.
Ropinirole's patent expired in May 2008, and the drug is now available in generic form.
Ropinirole acts as a D2, D3, and D4 dopamine receptor agonist with highest affinity for D3. It is weakly active at the 5-HT2, and α2 receptors and is said to have virtually no affinity for the 5-HT1, GABA, muscarinic, α1, and β-adrenoreceptors.
Ropinirole is metabolized primarily by cytochrome P450 CYP1A2, and at doses higher than clinical, is also metabolized by CYP3A4. At doses greater than 24 mg, CYP2D6 may be inhibited, although this has only been tested in vitro.
d sulfuric acid
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