Mepivacaine

Details:

Product Name: Mepivacaine
Synonyms: MEPIVACAINE;N-(2,6-Dimethylphenyl)-1-Piperidinecarboxamide;N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide;MepivacaineBase;Mepivacaine HCl (base);Mepivacaine N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide;Mepivacaine Impurity A;N-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamide
CAS: 22801-44-1
MF: C15H22N2O
MW: 246.35
EINECS: 1312995-182-4
Product Categories:
Mol File: 22801-44-1.mol
Mepivacaine Structure
Mepivacaine Chemical Properties
pka pKa 7.73(H2O,t =25±0.2,I=0.01(NaCl)) (Uncertain)
CAS DataBase Reference 22801-44-1(CAS DataBase Reference)
EPA Substance Registry System 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl- (22801-44-1)
Safety Information
MSDS Information
Mepivacaine Usage And Synthesis
Uses Local anesthetic.
General Description Mepivacaine hydrochloride is available in 1% to 3% solutionsand is indicated for infiltration anesthesia, dental procedures,peripheral nerve block, or epidural block. The onset of anesthesiais rapid, ranging from about 3 to 20 minutes for sensoryblock. Mepivacaine is rapidly metabolized in the liver with50% of the administered dose excreted into the bile asmetabolites. The metabolites are reabsorbed in the intestineand excreted in the kidney with only a small percentage foundin the feces. Less than 5% to 10% of the administered dose isfound unchanged in the urine. The primary metabolic productsare the N-demethylated metabolite and the 3 and 4 phenolicmetabolites excreted as their glucuronide conjugates.