organic intermediat...

organic intermediates, Patupilone CAS:152044-54-7
organic intermediates, Patupilone CAS:152044-54-7
organic intermediates, Patupilone CAS:152044-54-7
organic intermediates, Patupilone CAS:152044-54-7
organic intermediates, Patupilone CAS:152044-54-7

organic intermediates, Patupilone CAS:152044-54-7

Min.Order / FOB Price:Get Latest Price

1 Kilogram

FOB Price:USD 54.8000 -61.5000
  • Min.Order :1 Kilogram
  • Purity: 99.0%
  • Payment Terms : L/C,D/A,D/P,T/T,

Keywords

Patupilone 152044-54-7 organic intermediates

Quick Details

  • Appearance:White Powder
  • Application:Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours.
  • PackAge: Aluminum foil bag /Fiber drum / as customers' request.
  • ProductionCapacity:500|Metric Ton|Month
  • Storage:Store at -20°C
  • Transportation:By air; by sea; or as customers' request.

Superiority:

Our company has been in existence for 10 years since its establishment. We have our own unique team. The  company integrates independent research and development, production and sales. We have established famous  brands at home and abroad. At present, our customers have spread all over the world, we have rich  Transportation experience, we aim to serve customers, to help customers, solve problems for customers. Look  forward to working with you!

Details:

Patupilone is a White Powder.Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours.

Product Description

Function & Application

1.Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.
 
2.Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.
 
3.Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively). Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.
 
   All Key Manufacturers and Suppliers of Baoji Guokang have routine inspections to ensure they are in compliance with the standards set in place during the original Supplier Assessment Inspection.
 
Production Inspection Process:
Our Group service includes regular and thorough inspections throughout the manufacturing process, eliminating the need to employ additional quality control inspectors.
- Raw material before any production begins
- Pre-production samples to ensure specifications are being met
- In-process to confirm that standards are maintained
- Pre-shipping to ensure that the product arrives to the customer exactly as expected and is packaged
correctly to prevent any damage in transit.

   We can help operating split shipments, meeting the factory minimum quantity but ship them in 2 or 3 shipments with required gaps among. This allows you to move stock through your business without taking up space and capital.
We will arrange the subsequent shipments from our factory to your warehouse.
We can consolidate your small orders from multiple factories, delivering all at the same time to you or your customers,using the most cost-effective route available. At the time of order placement, we will offer details to you about the volume of each component part and what size container will be used.
  We can offer the complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.
   Delivery can be offered.
    - Utilizing your own freight-forwarder
    - FOB to a port in China
    - CIF to a port near you
   Whether you have your own freight-forwarder or you would like to organize shipment; whether you require delivery FOB in China or CIF to a port near you, we are glad to quote and supply whichever way you choose. Please feel free to discuss all options with us.

1.Client is first.We are trying to bring maximum profit to our clients and we only share small.
2.Credibility is the most important.
3.Quality control is our life.
4.Great sense of responsibility.
We will be responsible for not only our products, our clients, our suppliers, also the society.

 
   All Key Manufacturers and Suppliers of Baoji Guokang have routine inspections to ensure they are in compliance with the standards set in place during the original Supplier Assessment Inspection.
 
Production Inspection Process:
Our Group service includes regular and thorough inspections throughout the manufacturing process, eliminating the need to employ additional quality control inspectors.
- Raw material before any production begins
- Pre-production samples to ensure specifications are being met
- In-process to confirm that standards are maintained
- Pre-shipping to ensure that the product arrives to the customer exactly as expected and is packaged
correctly to prevent any damage in transit.

   We can help operating split shipments, meeting the factory minimum quantity but ship them in 2 or 3 shipments with required gaps among. This allows you to move stock through your business without taking up space and capital.
We will arrange the subsequent shipments from our factory to your warehouse.
We can consolidate your small orders from multiple factories, delivering all at the same time to you or your customers,using the most cost-effective route available. At the time of order placement, we will offer details to you about the volume of each component part and what size container will be used.
  We can offer the complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.
   Delivery can be offered.
    - Utilizing your own freight-forwarder
    - FOB to a port in China
    - CIF to a port near you
   Whether you have your own freight-forwarder or you would like to organize shipment; whether you require delivery FOB in China or CIF to a port near you, we are glad to quote and supply whichever way you choose. Please feel free to discuss all options with us.

1.Client is first.We are trying to bring maximum profit to our clients and we only share small.
2.Credibility is the most important.
3.Quality control is our life.
4.Great sense of responsibility.
We will be responsible for not only our products, our clients, our suppliers, also the society.
Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.

 

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