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183319-69-9 Erlotinib hydrochloride Erlotinib hydrochloride Price
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Product Name |
erlotinib hcl |
CAS NO. |
183319-69-9 |
EINECS NO. |
C22H24ClN3O4 |
Molecular formula |
429.8967 |
Molecular weight |
548.2°C at 760 mmHg |
Other Name |
ERLOTINIB HCL SALT; Erlotinib, Hydrochloride Salt; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4- Hydrochloride; quinazolinamine, Hydrochloride Salt |
Erlotinib Hydrochloride is a small molecule inhibitor of the EGFR/HER-1 (human epidermal growth factor receptor) tyrosine kinase. Overexpression of the EGFR is present in many carcinomas, and inhibition of the activating kinase by Erlotinib provides a chemical intervention upon these systems. The inhibition of this tyrosine kinase effectively blocks EGFR activity but does not suppress tumor growth. When combined with 3,3'-diindolylmethane (sc-204624), efficacy against tumor proliferation was demonstrated.
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