Product Description

 

Name: Oligopeptide-104

Alias: P11-4

Sequence : Ac-Gln-Gln-Arg-Phe-Glu-Trp-Glu-Phe-Glu-Gln-Gln-NH2

Molecular formula: C72H98N20O22

Molecular weight : 1595.69

Purity: >95.0%

Source: synthetic

MSDS and COA: available

 

P11-4 is a synthetic, pH controlled self-assembling peptide used for biomimetic mineralization e.g. for enamel regeneration or as an oral care agent. P11-4 (INCI name Oligopeptide 104) consists of the natural occurring amino acids Glutamine, Glutamic acid, Phenylalanine, Tryptophan and Arginine. The resulting higher molecular structure has a high affinity to tooth mineral.

 

 

Mechanism of action

P11-4 is a self-assembling β-peptide. It builds a 3-D bio-matrix with binding sites for Calcium-ions serving as nucleation point for Hydroxyapatite (tooth mineral) formation. The high affinity to tooth mineral is based on matching distances of Ca-ion binding sites on P11-4 and Ca spacing in the crystal lattice of hydroxyapatite. The matrix formation is pH controlled and thus allows control matrix activity and place of formation.

 

P11-4 in Dental applications

Self assembling properties of P11-4 are used to regenerate early caries lesions. By application of P11-4 on the tooth surface, the peptide diffuse through the intact hypomineralized plate into the early caries lesion body and start, due to the low pH in such a lesion, to self-assemble generating a peptide scaffold mimicking the enamel matrix. Around the newly formed matrix de-novo enamel-crystals are formed from calcium phosphate present in saliva. Through the remineralization caries activity is significantly reduced in comparison with a fluoride treatment alone. In aqueous oral care gels the peptide is present as matrix. It binds directly as matrix to the tooth mineral and forms a stable layer on the teeth. This layer does protect the teeth from acid attacks. It also occludes open dentin tubule and thus reduces the dental sensitivity

 

 

 

 

 

Service we can Provide

1. provide costomers with "one-stop"packaging service,from manufacture ,research,development,production,export and so on
2. Quality control, before shipment.
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment

5.Mix and different products in ONE PCL,increase the working efficiency for customers.

6.We can export from many China main ports,convenient for the customes provide logistics services.

7..Alibaba gold members with high credit guarantee.

Our Advantages:
Full experience of large numbers containers loading in Chinese sea port
Fast shipent by reputed shipping line
Packing with pallet as buyer's special request
Cargoes together with container sales service available
Cargoes photo before and after loading into container
Raw materials from Chinese origin

 

Packaging & Shipping

Packaging:

plastic/glass bottle, aluminium foil bag or customized according to requests, well protected.

 

 

 

Shipping:

FedEx/DHL/EMS or by air.

 

Our Services

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If you have any questions or need a sample ,pls contact us:)