1 Gram	FOB Price: USD 1.0000

Min.Order :1 Gram
Purity: 98% HPLC
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

2353-33-5 5-Aza-2'-deoxycytidine 5-Aza-2'-deoxycytidine Price

Quick Details

Appearance:White powder
Application:pharmaceutical intermediates
PackAge:1kg or 25Kg drum
ProductionCapacity:3000|Metric Ton|Year
Storage:Store in dry, dark and ventilated place
Transportation:By air or by sea. Prompt delivery

Superiority:

Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

We promise our customer following items

1.Reasonable price:
2.Low moq:No worry about the low moq, our moq is 1 gram or lower.
3.Good and efficient service,Fast Delivery
4.Super-good quality

Details:

5- aza -2'- deoxycytidine also known as decitabine, 5- aza -2 '- deoxycytidine monophosphate, adenosine analogues is a natural 2' - deoxycytidine acid, by inhibiting DNA methyltransferase, reduced DNA methylation, thus inhibit the proliferation of tumor cells and prevent drug resistance. Is currently the strongest known methyl DNA specific inhibitor, which belongs to the S phase of the cell cycle specific drug for the treatment of myelodysplastic syndrome (MDS).

Demethylation drugs can activate tumor cell tumor suppressor genes and enhance the expression of regulatory genes such as differentiation genes, so that MDS can be used for the treatment of cancer. The 5- aza -2'- deoxy cytidine, which has been phosphorylated, exerts its antitumor effects. It acts directly on DNA and inhibits DNA methyltransferase, which causes DNA hypomethylation and cell differentiation and death. DNA inhibits DNA methylation in vitro, but does not affect the synthesis of dna. It can lead to demethylation of tumor cells and restore the normal function of genes, which is important for controlling cell differentiation and proliferation. However, non proliferating cells are insensitive to capecitabine.

Is a kind of epigenetic modification, can inhibit DNA methyltransferase activity, causing demethylation in DNA (methylation) and open chromatin remodeling by activating gene; when demethylation and histone acetylation when combined, synergistic activation gene 5 '- deoxycytidine; nitrogen DNA induced demethylation or semi demethylation; DNA demethylation can regulate gene expression, can improve the quality of nuclease sensitivity detection structure through the "open" staining, the remodeling of chromatin structure, allowing transcription factor connection gene promoter, transcription complex assembly and gene expression

There is an antitumor activity in the lung, and it is a dual mechanism of dose difference. It has cytotoxicity at high concentration and demethylation at low concentration. Acting on proliferating (stage S) cells.