VH 298

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Purity: ≥98% by HPLC

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VH 298 (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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Application:VH 298 is a cell-permeable and high affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). VH 298 blocks VHL interacting with HIF-α downstream of HIF-α hydroxylation, leading to time- an...
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BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.

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