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23828-92-4 Ambroxol hydrochloride Ambroxol hydrochloride Price
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Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or
excessive mucus. It is the active ingredient of Mucosolvan, Mucobrox, Lasolvan, Mucoangin, Surbronc and Lysopain. The substance is a mucoactive drug with several properties including secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract, which play an important role in the body’s natural defence mechanisms. It stimulates synthesis and release of surfactant by type II pneumocytes. Surfactants acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents.
Name |
Ambroxol hydrochloride |
Synonyms |
trans-4-[[(2-Amino-3,5-dibromo-phenyl)methyl]amino]-cyclohexanol hydrochloride |
Brand |
Salus |
Molecular Formula |
C13H18Br2N2O.HCl;C13H19Br2ClN2O |
Molecular Weight |
414.57 |
CAS Registry Number |
23828-92-4 (15942-05-9) |
Appearance |
White or yellowish crystalline powder |
Appearance of solution |
Not more intensely colored than the reference solutionY6 |
Melting point |
235 ~ 240°C |
Solubility |
A) Water: sparingly soluble |
|
B) Methanol: soluble |
|
C) Methylene Chloride: practically insoluble |
Identification |
A) UV Absorption: 3.2 ~ 3.4 |
|
B) IR Spectrum |
|
C) TLC |
|
D) Chlorides Test |
Related substances |
Individual impurity: 0.1% Max |
|
Total impurities: 0.3% Max |
Heavy metals |
20ppm Max |
Loss on drying |
Loss on drying |
Sulfated ash |
0.1% Max |
PH (1% aqueous solution) |
4.5 ~ 6.0 |
Assay |
99.0 ~ 101.0% |
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