54-85-3 Isoniazid Isoniazid Price
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Isoniazid is an antibacterial agent used primarily as a tuberculostatic. Target: Antibacterial Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing.
Name |
Isoniazid |
Synonyms |
Isonicotinic acid hydrazide; INAH; Pyridine-4-carbohydrazide |
Brand |
Qindgao Sigma Chemical Co.,Ltd |
Molecular Formula |
C6H7N3O |
Molecular Weight |
137.14 |
CAS Registry Number |
54-85-3 |
EINECS |
200-214-6 |
Items |
Standard |
Results |
Characters |
A white crystalline powder or colorless crystals |
A white crystalline powder |
Identification |
Conforms |
Conforms |
Melting Point |
170-174°C |
171-172°C |
PH |
6.0-8.0 |
7.1 |
Solution Colour |
Conforms |
Conforms |
Clearness |
Conforms |
Conforms |
Hydrazine and related substances |
Conforms |
Conforms |
Loss on drying |
≤0.5% |
0.11% |
Sulphate ash |
≤0.1% |
0.02% |
Heavy Metals |
≤0.001% |
<0.001% |
Assay |
99.0~101.0% |
99.40% |
Packing |
25kg woven bag packaging, plastic-lined;According to user requirements to provide various types of packaging |
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