CasNo.59-05-2,High Quality Methotrexate,(59-05-2) Suppliers

1 Gram	FOB Price: USD 1.0000

Min.Order :1 Gram
Purity: 98% HPLC
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

59-05-2 Methotrexate Methotrexate Price

Quick Details

Appearance:White powder
Application:pharmaceutical intermediates
PackAge:1kg or 25Kg drum
ProductionCapacity:3000|Metric Ton|Year
Storage:Store in dry, dark and ventilated place
Transportation:By air or by sea. Prompt delivery

Superiority:

Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

We promise our customer following items

1.Reasonable price:
2.Low moq:No worry about the low moq, our moq is 1 gram or lower.
3.Good and efficient service,Fast Delivery
4.Super-good quality

Details:

Quick Details

CAS No.:: 59-05-2

Other Names:: Methylaminopterin

MF:: C20H22N8O5

EINECS No.:: 200-413-8

Place of Origin:: Shandong, China (Mainland)

Type:: Anesthetic Agents

Grade Standard:: Medicine Grade

Usage:: Animal Pharmaceuticals

Brand Name:: Qindgao Sigma Chemical Co.,Ltd

Model Number:: Methotrexate

Purity:: 99%

Molecular Weight:: 454.44

Melting point:: 195℃

Water solubility:: Insoluble. <0.1 g/100 mL at 19℃

Hazard Symbols:: T:Toxic;

Risk Codes:: R61:; R25:; R36/38

Safety Description:: S53:; S26:; S36/37:; S45:;

Application:: A cell cycle arresting agent that inhibits DHFR

Appearance:: Powder

Physical State:: Solid

Storage:: Store at -20° C

Supply Ability

Supply Ability:: 6000 Kilogram/Kilograms per Month

Packaging & Delivery

Packaging Details: 5/10/25 kg /drum or according to customer's requiement

Port: qingdao port

Lead Time :: Shipped in 3 days after payment

Product Description

Description

Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate arrests the cell cycle in late G1/S-phase, therefore inhibiting the synthesis of DNA, RNA, thymidylates, and proteins. In the previous cases the inhibition of enzymes involved in purine metabolism, leading to accumulation of adenosine, or the suppression of intercellular adhesion molecule expression by T cells as the main mechanism of action by methotrexate. The compound has been observed to irreversibly inhibit dihydrofolate reductase (DHFR) and thymidylate synthetase (TS). Methotrexate has been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. In adherent splenic cells, IL-1 production was decreased by methorexate.

specification

Text	USP27	EP4	BP2002
Assay%	98.0-102.0	98.0-102.0	98.0-102.0
Residue on ignition%	≤0.1
Specific roataion	+19-+24	+19-+24
Loss on drying%
Chromatographic purity%	≤2.0(total)
	≤0.5(individual)
Water%	≤12.0	≤13.0	≤12.0
Organic Volatile impurites	conforms
Sulphated ash%		≤0.1	≤0.1
Heavy metals ppm		50	1
Related substance
Total		≤1.3	≤1.3%
Individual		At most five peaks	At most five peaks
Impurity A%		≤0.5	≤0.5
Impurity B%		≤0.5	≤0.5
Impurity C%		≤0.5	≤0.5
Impurity D%		≤0.5	≤0.5
Impurity E%		≤0.5	≤0.5
Unknown Impurity %		≤0.5	≤0.5
(R)-Methotrexate%		≤3.0	≤3.0