Diacerein CAS NO.13739-02-1

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10 Gram	Negotiable

10 Gram

Negotiable

Min.Order :10 Gram
Purity: 99%
Payment Terms : T/T,Other

Keywords

Diacerein CAS NO.13739-02-1 13739-02-1; C19H12O8 Diacerein, C19H12O8

Quick Details

Appearance:powder
Application:Pharmaceutical Intermediates
PackAge:foil bags, drums or bottles
ProductionCapacity:100|Kilogram|Month
Storage:Dry and ventilated
Transportation:sea,air,express

Superiority:

Product Details

Keywords

Diacerein
Diacerein,C19H12O8
13739-02-1,chemical

Quick Details

ProName:Diacerein
CasNo:13739-02-1
Molecular Formula:C19H12O8
Appearance:powder
Application:Pharmaceutical Intermediates
DeliveryTime:within 1-2days
PackAge:bag
Port:tianjin port
ProductionCapacity:100 Metric Ton/Month
Purity:99
Storage:dry
Transportation:by air
LimitNum:1 Gram

Superiority

product name:	diacerein
synonyms:	1,8-diacetoxy-3-carboxyanthraquinone;diacerein;diacerhein;diacetyl rhein;1,8-diacetoxyanthraquinone-3-carboxylicacid;4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylicaci;4,5-diacetylrhein;9,10-dihydro-4,5-diacetoxy-9,10-2-anthracenecarboxylicacid
cas:	13739-02-1
mf:	c19h12o8
mw:	368.29
einecs:	237-310-2
product categories:	miscellaneous biochemicals;aromatics compounds;aromatics;heterocycles;intermediates & fine chemicals;pharmaceuticals

Details

Diacerein Usage And Synthesis

Immunosuppressive drugs	Diacerein is a novel interleukin (IL) -1 inhibitor , the chemical name is diacetyl rhein,it is a compound of anthraquinones, the product can induce cartilage generation, it has analgesic, antipyretic and anti-inflammatory effects, but also it can significantly improve joint function in patients with osteoarthritis, and delay duration, and reduce pain to improve the quality of life of patients, it has better security, it is mainly used in clinical treatment of osteoarthritis (OA) to exert an antibacterial effect. Solubility: soluble in dimethyl sulfoxide, dimethyl acetamide; insoluble in water, methanol, chloroform. Diacerein and its active metabolite rhubarb (rhein) can reduce the generation and activity of IL-1β by inhibiting IL-1 converting enzyme. Mechanisms include: 1, inhibit the IL-1 synthesis of synovial tissue. 2, inhibit the expression of IL-1 receptor in chondrocytes . 3, inhibition of IL-1 activity. 4, repress formation of metalloproteinases such as collagenase and matrix dissolved elements and peroxide. 5, promote the synthesis of collagen and glycosaminoglycan. 6, inhibit the leukocyte chemotaxis and lysosomal stability. Diacerein does not change the cyclooxygenase activity of kidneys and platelets, and does not inhibit the synthesis of prostaglandin , so prostaglandin-dependent renal dysfunction patients can tolerate. Oral 50mg, PPB is 99%, Tmax is 2.2 h, Cmax is 3.2 mg / L, AUC is 21.3 mg • h / L, T1 / 2β is 4.3 h. Tmax and AUC values can be increased if it is administrated with food . Adverse reactions: 50% of patients suffer diarrhea, abdominal pain and loose stools. The above information is edited by the chemicalbook of Tian Ye.
Application	It is widely used in new liquid crystal polymer, engineering plastics and high-strength fibers with high performance. This product is an important osteoarthritis IL-1 inhibitor. It is used for osteoarthritis. It is a natural antioxidant, it has anti-aging, enhance immunity, removing sub-health state, physical recovery, increasing energy and body immunity effects.
Chemical Properties	Yellow Crystalline Solid
Usage	A diacetyl derivative of Rhein. Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic
Usage	antiinflammatory
Usage	A diacetyl derivative of Rhein (R318500). Demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis. Antiarthritic.
Usage	Treatment of Osteoarthritis (Prevent cartilage destruction)

Details:

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