CasNo.120014-06-4,High Quality Donepezil/Donepezil hcl,(120014-06-4) Suppliers

1 Gram	FOB Price: USD 1.0000

Min.Order :1 Gram
Purity: 98% HPLC
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

120014-06-4 Donepezil Donepezil hcl Price

Quick Details

Appearance:White powder
Application:pharmaceutical intermediates
PackAge:1kg or 25Kg drum
ProductionCapacity:3000|Metric Ton|Year
Storage:Store in dry, dark and ventilated place
Transportation:By air or by sea. Prompt delivery

Superiority:

Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

We promise our customer following items

1.Reasonable price:
2.Low moq:No worry about the low moq, our moq is 1 gram or lower.
3.Good and efficient service,Fast Delivery
4.Super-good quality

Details:

Product Description

Product name Donepezil

Appearance: White or off-white crystalline powder

CAS NO. 120014-06-4

Molecular Formula C24H29NO3

Molecular Weight 379.49200

Melting point 207ºC

Boiling point 527.9ºC at 760mmHg

Density 1.141g/cm3

Flash point 273.1ºC

Donepezil hydrochloride is a therapeutic treatment of Alzheimer's drugs,compared with similar drugs have a low incidence of adverse reactions and efficacy obvious feature is the only way to reach the U.S. Food and Drug Administration standard treatment guidelines for Alzheimer's disease drug, is the only one species while the FDA approved the listing of new drugs and UK MCA for the treatment of mild to moderate Alzheimer's.

Certification of Analysis

TESTS	RESULTS	SPECIFICATIONS
APPEARANCE	Complies	White or almost white crystalline powder
IDENTIFICATION	Complies	A: By IR, To match with working standard
	Complies	B: By UV, To match with working standard.
TEST
Melting point	91℃-94℃	90℃-94℃
Residue on ignition	0.18%	≤ 0.2%
Heavy metals	< 0.001%	≤ 0.001%
Related substances	0.07%	≤ 1.0%
Water	0.11%	≤ 1.0%
ASSY	99.63%	≥99.0%

Function&Application

Function

Mild or moderate Alzheimer-type dementia treatment.

Donepezil hydrochloride is a long-acting Alzheimer's disease (AD) in the symptomatic treatment drugs.

AD is a kind of memory loss as the main performance, accompanied by other cognitive impairment of acquired intelligence decline. Nearly 30 years of research show: AD progressive degeneration of cholinergic neurons is memory loss, disorientation, personality changes and behavioral reasons,such cholinergic theory has been confirmed by histological study. Donepezil hydrochloride is a second-generation cholinesterase (ChE) inhibitor, its therapeutic effect is reversibly inhibiting acid hydrolysis of acetylcholine acetylcholinesterase (AchE) caused by increased content of acetylcholine receptor sites.

Donepezil may have other mechanisms, including the disposal of the direct effect of the peptide,neurotransmitter receptors, or Ca2 + channels.

Donepezil hydrochloride selection of AchE affinity than to butyrylcholinesterase (BchE) 1250 times stronger,it can inhibit the brain tissue ChE, but on the heart (myocardium) or small intestine (smooth) had no effect,probably on the chest organization (rhabdomyosarcoma) role; on the central nervous toxicity than tacrine.

Application

1. adult / elderly: initial treatment dosage 5mg / day (day 1). The product should be orally at bedtime at night.

Doses of 5mg / day should be maintained at least - months to evaluate early clinical response, and donepezil hydrochloride reach steady-state plasma concentrations. After using 5mg / day treatment a month, making clinical evaluation may be the product of the dose to 10mg / day (day 1). The maximum recommended dose is 10mg.

Greater than 10mg / day dose clinical trials have not done. We did not conduct placebo-controlled clinical trials with more than six months. After stopping treatment, the efficacy of the product gradually diminishes. Discontinuation of treatment no rebound phenomenon.

2. liver and kidney damage: For mild to moderate renal and hepatic dysfunction, donepezil hydrochloride elimination is not affected, so these patients can use a similar dose schedule.

Our Advantages

1.Competitive price
2.Fast Delivery Within 3 days
3.SGS,BV,GMP,ISO approve
4.Professional factory