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56390-09-1 Epirubicin hydrochloride Epirubicin hydrochloride Price
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Description
Epirubicin Hydrochloride is a cell-permeable antitumor antibiotic. A stereoisomer of Doxorubicin (sc-280681) that exhibits reduced cardiotoxicity. Epirubicin Hydrochloride’s antitumor actions are mediated by targeting and inhibiting Topo II (topoisomerase II).
Product Name: Epirubicin HCl
Synonyms: epirubicin hydrochloride; l-erythro-dihydrosphingosine; (1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside hydrochloride (1:1)
Molecular Formula: C27H29NO11
Molecular Weight: 543.5193
InChI: InChI=1/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17+,22-,27-/m0/s1
CAS Registry Number: 56390-09-1
EINECS: 260-145-2
Density: 1.61g/cm3
Boiling point: 810.3°C at 760 mmHg
Refractive index: 1.709
Flash point: 443.8°C
Vapour Pressur: 9.64E-28mmHg at 25°C
Specification
Test |
Specification |
|
Appearance |
White powder |
|
Solubility |
Soluble in water or in methanol, slightly soluble in anhydrous ethanol, practically insoluble in acetone. |
|
Identification |
A) IR absorption spectrum be consistent with that of its CRS. |
|
B) HPLC: The retention time of principal peak is similar in that of its reference peak. |
||
C) Exhibits the precipitate reaction of Ag+. |
||
PH |
4.0-5.5 |
|
Water |
NMT 4.0% |
|
Bacterial endotoxins |
NMT 1.1 IU/mg |
|
Related substances |
Doxorubicino NMT 1.0% |
|
Doxorubicin NMT 1.0% |
||
Impurity B: NMT 0.5% |
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Impurity D: NMT 0.5% |
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Impurity E: NMT 0.5% |
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Impurity F: NMT 0.5% |
||
Impurity G: NMT 0.5% |
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Any other unknown impurity: NMT 0.1% |
||
Total impurities: NMT 2.0% |
||
Assay |
97.0% ~ 102.0% |
|
Conclusion |
Conforms to the requirements of EP7.0 standards. |
CAS NO:30123-17-2
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