136310-93-5 Tiotropium bromide Tiotropium bromide Price
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Product Name:Tiotropium bromide
CAS:136310-93-5
MF:C19H22BrNO4S2
MW:472.42
Apperance:White Solid
Usage:Muscarinic receptor antagonist. Bronchodilator
TEST ITEM |
SPECIFICATION |
RESULT |
Appearance |
White or off white crystalline powder |
Complies |
Identification |
By IR absorption ,To match with working standard |
Complies |
UV spectrum ,there is a maximum absorption at 236nm. |
Complies |
|
Solubility |
Slightly solubily in water,very slightly in ethanol and acetonitrile |
Complies |
Test |
||
Melting point |
217~222°C |
218~220°C |
pH |
4.0~7.0 |
5.68 |
Loss on drying |
≤1.0% |
0.32% |
Single Impurity Total impurity |
≤0.3% ≤0.5% |
Complies 0.23% |
Heavy metal |
≤20ppm |
<20ppm |
Residue on ignition |
≤0.1% |
Complies |
Assay |
≥99.00% |
99.76% |
Conclusion:Conforms |
Tiotropium is a muscarinic receptor antagonist, often referred to as an antimuscarinic or anticholinergic agent. Although it does not display selectivity for specific muscarinic receptors, on topical application it acts mainly on M3 muscarinic receptorslocated on smooth muscle cells and submucosal glands not to produce smooth muscle contration and mucus secretion, thus producing a bronchodilatory effect.
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