72509-76-3 Felodipine Felodipine Price
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Description
Felodipine is a 1,4-dihydropyridine small molecule antagonist and calcium channel protein inhibitor. Antagonism of the vascular L-
type (long-lasting) calcium channel decreases intracellular calcium concentration, softening the tone of vascular tissue and
decreasing the peripheral resistance upon the blood stream, effectively decreasing systemic arterial blood pressure without
affecting myocardial contractility. Felodipine is described to inhibit cytokine-induced NO and superoxide production as well as
cytokine-induced NO synthase (NOS) mRNA induction, and is suggested to act as a scavenger of superoxide and not an inhibitor
of inducible NOS induction. This indicates that Felodipine further protects the vasculature against endogenous free radical
generation during inflammatory responses.
Specification
Items |
Standard |
||
Character |
White or almost white crystalline powder |
||
Identification |
Positive |
||
Residue on ignition |
≤0.5% |
||
Heavy metals |
NMT 20ppm |
||
Arsenic |
NMT 5ppm |
||
Sulphated ash |
NMT 0.1% |
||
Loss on drying |
NMT 0.5% |
||
Total impurities |
NMT 1.5% |
||
Assay(HPLC) |
97%-103% |
CAS NO:30123-17-2
CAS NO:171596-29-5
CAS NO:171596-29-5
CAS NO:171596-29-5
CAS NO:171596-29-5
CAS NO:171596-29-5
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