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119478-56-7 meropenem trihydrate meropenem trihydrate Price
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Antibiotic Powder Meropenem Powder CAS 119478-56-7 :
Meropenem is bactericidal except against Listeria monocytogenes where it is bacteriostatic. It inhibits bacterial wall synthesis like other beta-lactam antibiotics. In contrast to other beta-lactams, it is highly resistant to degradation by beta-lactamases or cephalosporinases. Resistance generally arises due to mutations in penicillin binding proteins, production of metallo-beta-lactamases, or resistance to diffusion across the bacterial outer membrane.[2] Unlike imipenem, it is stable to dehydropeptidase-1 and can therefore be given without cilastatin
Specification:
Items |
Specification |
Results |
|
Appearance |
White or off-white powder |
Conformed |
|
Identification |
Meets the requirements |
Conformed |
|
pH |
7.3-8.3 |
8.1 |
|
Loss on drying |
9.0%~12.0% |
10.2% |
|
Chromatographic |
RRT(0.45) |
0.80% MAX |
0.13% |
purity |
RRT(1.90) |
0.60% MAX |
0.15% |
Particulate matter |
≥10 um |
≤6000 pc/g |
Conformed |
≥25 um |
≤600 pc/g |
Conformed |
|
Uniformity of dosage unites |
Meets the requirements |
conformed |
|
Bacterial endotoxinsunder |
≤0.125EU/mg |
Conformed |
|
Sterility |
Meets the requirements |
Conformed |
|
Content of sodium |
5.3%-8.0% |
6.8% |
|
Assay(C17H25N3O5S) on anhydrous basis |
≥ 76.0% |
80.7% |
|
Conclusion |
The product conforms the USP30 standard |
||
Packing storage |
In tight containers, the dry powder at controlled room temperature |
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