CasNo.74103-07-4,High Quality Toradol,(74103-07-4) Suppliers

1 Gram	FOB Price: USD 1.0000

Min.Order :1 Gram
Purity: 98% HPLC
Payment Terms : L/C,D/A,D/P,T/T,

Keywords

74103-07-4 Toradol Toradol Price

Quick Details

Appearance:White powder
Application:pharmaceutical intermediates
PackAge:1kg or 25Kg drum
ProductionCapacity:3000|Metric Ton|Year
Storage:Store in dry, dark and ventilated place
Transportation:By air or by sea. Prompt delivery

Superiority:

Qingdao Sigma Chemical Ltd is is a global chemical industry manufacturers and suppliers of pharmaceuticals and intermediates, peptide,Nootropis etc API, food and feed additives, herbal extracts, agrochemicals and fine chemicals etc.

Our Laboratory is located in shandong province. There are 15 experts in our research team. Talented personnel and well-equipped laboratory makes rigorous and professional quality control possible. Lyphar Biotech is equipped with various detection devices, such as HPLC, GC, Spectrophotometer, AAS, Polarimeter, Auto titrators, BOD Incubators, COD Incubators, Melting point apparatus and so on.

The aim of QDSIGMA is a quality policy that "Elements in the system all have been satisfied, Personnel has been trained; Every batch of material is checked, Each procedure guarantees the quality; Every bag of our products is top grade, Service is thoughtful all the time, quality and reputation to increase market share and promote enterprise development. The quality, colors and forms of our products have reached a high level in related chemical industry, which relies on characteristic and advanced processing technology and it has gained a high and reliable reputation from customers at both quality and services.

QDSIGMA has become the "Top 500 Chinese manufacturing companies","Top 20 of global chemical sales".QDSIGMA has 21 subsidiaries and holding companies.

We promise our customer following items

1.Reasonable price:
2.Low moq:No worry about the low moq, our moq is 1 gram or lower.
3.Good and efficient service,Fast Delivery
4.Super-good quality

Details:

Supply Toradol, Ketorolac Tromethamine 74103-07-4

Product Description

Ketorolac (tromethamine salt) inhibits both isoforms of Cox in recombinant rat and human enzyme systems. Ketorolac inhibits rat Cox-1 (IC50 of 0.27 μM), rat Cox-2 (IC50 of 2.06 μM), human Cox-1 (IC50 of 1.23 μM) and human Cox-2 (IC50 of 3.50 μM). The (S) enantiomer of Ketorolac with rat Cox-1 (IC50 of 0.10 μM) is approximately twice as potent as the racemate, whereas the (R)-enantiomer (IC50 of > 100 μM) is virtually without activity. Ketorolac shows inhibition of eicosanoid formation in HEL cells (Cox-1, IC50 of 0.025 μM) and LPS-stimulated Mono Mac 6 cells (Cox-2, IC50 of 0.039 μM), but does not significantly inhibit NO accumulation in supernatants of LPS-stimulated RAW 264.7 cells up to 300 μM. Ketorolac significantly inhibits thymidine incorporation of human osteoblasts (hOBs) upon 24 hours treatment in a dose-dependent manner, and inhibits proliferation and arrests cell cycle at G0/G1 phase in hOBs.

Specification

TESTS	SPECIFICATIONS	RESULTS
Appearance	White or almost white, crystalline powder	Almost white crystalline powder
Solubility	Freely soluble in water and in methanol; slightly soluble in alcohol, in dehydrated alcohol, and in tetrahydrofuran; practically insoluble in acetone, in dichloromethane, in toluene, in ethyl acetate,in dioxane,in hexane,in butyl alcohol,and acetonitrile	Conforms
Identification	UV:Maximum absorption at 243nm,318nm.Minimum absorption at 268nm	Conforms
	TLC:color and position of principal spot obtained with test solution consistent with that of the reference solution	Conforms
	IR	Conforms
pH	5.7~6.7	6.1
Melting range	165~170°C	166~168°C
Clarity and color of solution	The solution should be clear and colorless ,if not ,not more intensely turbid than No.1 reference solution and not more intensely colored than reference solution of Y1	Conforms
Related substances	1-ketone-ketorolac acid≤0.1%	0.0027%
	1-hydroxyl-ketorolac acid≤0.1%	N.D
	Other single impurity≤0.5%	0.12%
	Total impurities≤1.0%	0.17%
Dichloromethane	Peak area of dichloromethane in test solution is not more than that of reference solution	N.D
Loss on drying	≤0.5%	0.08%
Residue on ignition	≤0.1%	0.09%
Heavy metals	≤0.002%	Conforms
Assay (on the dried basis)	98.5~101.5%	99.2%
Conclusion	The product meets the requirements of USP

Function and Application

Ketorolac is indicated for short-term management of moderate to severe pain. Concerns about the high incidence of reported side effects led to restriction in its dosage and maximum duration of use. In the UK, treatment should be initiated only in a hospital. Maximum duration of treatment should not exceed five days for tablets (per package insert), or two days for continuous daily dosing with intravenous or intramuscular formulations. The ophthalmic formulation can be used instead of steroidal anti inflammatories in cases where a raised intraocular pressure (glaucoma) is to be avoided.

Packing and Storage

1kg with double plastic container inside/Aluminum foil bag ;
25kg with double plastic container inside/Fiber drum outside.Or as your request.
Shipped in 3 days after payment.
1.Stored in a cool and dry well-closed container and in ventilated area.
2.kept away from moisture and strong light or high temperature.
3.Two years under well storage situation and stored away from direct sun light.