BIMATOPROST(TM) CAS NO.155206-00-1

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10 Gram	Negotiable

10 Gram

Negotiable

Min.Order :10 Gram
Purity: 99%
Payment Terms : T/T,Other

Keywords

BIMATOPROST(TM) CAS NO.155206-00-1 155206-00-1 C25H37NO4,research

Quick Details

Appearance:powder
Application:Pharmaceutical Intermediates
PackAge:foil bags, drums or bottles
ProductionCapacity:100|Kilogram|Month
Storage:Dry and ventilated
Transportation:sea,air,express

Superiority:

Product Details

Keywords

Bimatoprost
155206-00-1,chemical
C25H37NO4,research

Quick Details

ProName:BIMATOPROST(TM)
CasNo:155206-00-1
Molecular Formula:C25H37NO4
Appearance:soild
Application:Orally active estrogenic steroid. It w...
DeliveryTime:3days
PackAge:in foil bag or customized
Port:Tianjin xingang
ProductionCapacity:10 Kilogram/Week
Purity:99%
Storage: 20°C
Transportation:shipping by courier or by sea
LimitNum:10 Gram
Related Substances:99%
Residue on Ignition:less than 0.5%
Heavy Metal:less than 0.5%
Valid Period:1 year

Superiority

product name:	bimatoprost
synonyms:	n-ethyl-9alpha,11alpha,15s-trihydroxy-17-phenyl-18,19,20-trinor-prosta-5z, 13e-dien-1-amide;lumigan;bimatoprost;bimatoprost(tm);17-phenyl trinor prostaglandin f2alpha ethyl amide;bimatoprost(lumigan);17-phenyl-tri-norprostaglandin f2α-ethyl amide;(z)-7-[(1r,2r,3r,5s)-3,5-dihydroxy-2-[(e,3s)-3-hydroxy-5-phenylpent-1-enyl]cyclopentyl]-n-ethylhept-5-enamide
cas:	155206-00-1
mf:	c25h37no4
mw:	415.57

Details

Bimatoprost Usage And Synthesis

Glaucoma Drug	Bimatoprost is a synthetic amide F2α derivative ,it can selectively simulate the effect forefront amines produced by the body, which make aqueous humor production rate increase aqueous outflow resistance is reduced, by increasing the amount of aqueous outflow of the uveoscleral and trabecular Netcom channel to reduce intraocular pressure (IOP),it is considered to be the most effective hypotensive drug of topical ocular anti-glaucoma drugs,it is suitable for the treatment of open-angle glaucoma (POAG) or invalid elevated intraocular other ocular hypotensive medications compression syndrome (OHT) patients.
Adverse reactions	1. to deepen the color of the iris, blepharitis, eye irritation and pain; black eyelashes thicker growth; conjunctival hyperemia, temporarily punctate corneal epithelial erosion, eyelid edema and erythema; rash. 2. rare respiratory disorders, asthma exacerbations, iritis, uveitis, eyelid skin darkening. 3. very rare chest pain, pharyngitis. 4. eye itching, allergic conjunctivitis, cataract, conjunctival edema, secretions, photophobia, superficial punctate keratitis, headache, high blood pressure.
Glaucoma commonly used drugs	1. prostaglandin derivatives such as latanoprost (Xalatan), bimatoprost (trade name Lumigan) and travoprost (Travatan) can increase outflow of aqueous humor uveoscleral . Bimatoprost also increases trabecular outflow. 2. topical β- adrenergic such as timolol, levobunolol (Betagan), and betaxolol can decrease receptor antagonist of aqueous humor production of ciliary body . 3. Alpha2 - adrenergic agonists such as brimonidine (Alphagan) with dual working mechanism, can reduce aqueous humor production and increase trabecular outflow. 4. one case of the selective reduction similar to epinephrine and dipivefrin (Propine) increase outflow of aqueous humor through trabecular meshwork and possibly through uveoscleral outflow pathway, probably by a β2- agonist action. 5. miotic agents (parasympathomimetics), if ciliary muscle contraction Roca works, it can tighten the trabecular and allow increaseing outflow of aqueous humor. Ecothiopate is used for chronic glaucoma. 6. dorzolamide (Trusopt), brinzolamide (Azopt), by inhibiting carbonic anhydrase acetazolamide of ciliary body, reduce aqueous humor secretion of carbonic anhydrase inhibitors. 7. Physostigmine is also used to treat glaucoma and delayed gastric emptying. The above information is edited by the Chemicalbook of Tian Ye.
Bimatoprost - timolol maleate compound eye drops	In July 2006 , bimatoprost - timolol maleate compound eye drops developed by the United States company obtained approval from the European drug regulatory authority for reducing intraocular pressure or ocular hypertension of open-anglepatients glaucoma patients who do not respond adequately to the β-blockers or prostaglandin like treatment . The compound eye drops containing 0.03% bimatoprost and 0.5% timolol maleate, once a day administration is able to provide clinically effective pressure control, the effect is better than single Bima latanoprost or timolol maleate. Clinical trials prove that the drug has an excellent tolerability, including the incidence of ocular hyperemia40% lower compared to single bimatoprost .
Chemical Properties	Crystalline Solid
Usage	Antiglaucoma. Synthetic prostamide; structurally related to prostaglandin F2a.
Usage	Antiglaucoma. Synthetic prostamide; structurally related to prostaglandin F2α.
Usage	Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. It ha
Usage	Bimatoprost is an antiglaucoma agent. Bimatoprost is an synthetic prostamide; structurally related to prostaglandin F2α.

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