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136572-09-3 Irinotecan hydrochloride trihydrate C33H45ClN4O9
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Irinotecan Hydrochloride Trihydrate CAS 136572-09-3
Irinotecan hydrochloride trihydrate Basic information |
Product Name: | Irinotecan hydrochloride trihydrate |
Synonyms: | Irinotecan hydrochloride trihydrate, >=99%;Irinotecan HCL 3H2O;rinotecan hydrochloride trihydrate;(1,4’-bipiperidine)-1’-carboxylicacid,4,11-diethyl-3,4,12,14-tetrahydro-4-hyd;roxy-3,14-dioxo-1h-pyrano(3’,4’:6,7)indolizino(1,2-b)quinolin-9-ylester,mono;trihydrate,(s)-hydrochlorid;IRINOTECAN HYDROCHLORIDE TRIHYDRATE;IRINOTECAN MONOHYDROCHLORIDE TRIHYDRATE |
CAS: | 136572-09-3 |
MF: | C33H45ClN4O9 |
MW: | 677.18 |
EINECS: | 1308068-626-2 |
Product Categories: | Inhibitors;Anticancer;API;Anti-cancer&immunity |
Mol File: | 136572-09-3.mol |
Irinotecan hydrochloride trihydrate Chemical Properties |
Melting point | 250-256°C (dec.) |
Boiling point | 257°C(lit.) |
Merck | 14,5091 |
CAS DataBase Reference | 136572-09-3(CAS DataBase Reference) |
Irinotecan hydrochloride trihydrate Usage And Synthesis |
Chemical Properties | White powder |
Uses | A DNA topoisomerase inhibitor. |
Definition | ChEBI: A hydrate that is the trihydrate form of irinotecan hydrochloride. Onivyde is used in combination with fluorouracil and leucovorin, for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine based therapy. It is converted via hydrolysis of the carbamate linkage to its active metabolite, SN-38, which is ~1000 times more active. |
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