112887-68-0 Raltitrexed Raltitrexed Price
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Description of Raltitrexed
[English Name] Raltitrexed
[Test Method]HPLC
[Purity]≥99%
[CAS No.] 112887-68-0
[Mol. Formula] C21H22N4O6S
[Mol. Weight]458.49
[Purity]> 99% by HPLC
For raltitrexed is a thymic synthetase inhibitor, is a quinazoline folate analogues. In the body, for raltitrexed uptake by cells active radical polymerization by folic acid metabolism of glutamate synthase soon after as a series of polyglutamic acid, Bireh for raltitrexed has more of these metabolites inhibit thymus synthetase, thus inhibiting cell DNA synthesis and retention in cells, long time inhibition effect. In the treatment of colorectal cancer, effects and fluorouracil is similar, but used for raltitrexed low incidence of side effects, the method is simple, easily accepted by patients.
Specification of Raltitrexed
Item |
Specification |
Result |
Appearance |
White powder |
Complies |
Related substance (HPLC) |
Total impurity ≤0.5% Max single impurity ≤0.1% |
0.2% 0.06% |
Odor |
Characteristic |
Complies |
Assay |
99% |
99.8% |
Sieve analysis |
100% pass 80 mesh |
Complies |
Loss on Drying Residue on Ignition |
≤1.0% ≤1.0% |
0.12% 0.09% |
Heavy Metal |
<10ppm |
Complies |
As |
<0.1pm |
0.05ppm |
Pb |
<0.1ppm |
0.05ppm |
Cd |
<0.1ppm |
0.05ppm |
Residual Solvents |
<100ppm |
Complies |
Residual Pesticide |
Negative |
Complies |
Microbiology |
|
|
Total Plate Count |
<1000cfu/g |
Complies |
Yeast & Mold |
<100cfu/g |
Complies |
E.Coli |
Negative |
Complies |
Salmonella |
Negative |
Complies |
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