18683-91-5 Ambroxol Ambroxol Price
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oxol | CAS 18683-91-5 | Brand: Qindgao Sigma Chemical Co.,Ltd |
MW:378.1 | MSDS: Avaiable | |
MF:C13H18Br2N2O | Sample: Avaiable | |
Category:API | Min order: 10grams | |
Quality standard : CP2005,USP28 |
Place of Origin:China | |
Introduction | Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. | |
Character | A white or almost white crystalline powder | |
Application | Pharmaceutical raw materials |
Ambroxol is bromhexine in the body of the active metabolite, as mucolytic drugs, the role of stronger than bromine has been new, usually use its hydrochloride. Ambroxol can be directly on the bronchial glands, mucosal secretion of cells to promote the release of lysosomes, the mucopolysaccharide fiber splitting splitting; also inhibit the goblet cells and goblet cells acidic glycoprotein synthesis, so that Secretion of low viscosity of small molecules of glycoprotein, leaving the viscosity of sputum decreased, easy to cough up. In addition, the goods can also stimulate the gastric mucosal reflex caused by increased secretion of respiratory glands, sputum dilution. Clinical for acute and chronic bronchitis and bronchiectasis, bronchial asthma, emphysema and other diseases of the expectorant; a history of respiratory patients with preoperative medication can prevent intraoperative pulmonary complications; lung tumor chemotherapy, radiotherapy-induced lung Fibrosis, silicosis and other causes of lung damage caused by a protective effect.
Item | Standard | Result | ||||
Appearance | White or off-white crystalline powder odorless, bitter taste | Conforms | ||||
IR Absorption | Consist with the spectra obtained with Cimetidine CRS. | Conforms | ||||
UV Absorption | Should conform | Conforms | ||||
Melting point | 233-234°C | 233-234°C | ||||
Heavy metal | ≤20ppm | <20ppm | ||||
Residue on ignition | ≤0.2% | 0.02% | ||||
Related substances | Single impurity≤0.2% | 0.15% | ||||
Total impurity≤1.0% | 0.47% | |||||
Loss on drying | ≤1.0% | 0.06% | ||||
Organic volatile impurities (ethanol) (loss on drying) |
≤0.5% | 0.06% | ||||
Assay (calculated with reference on dried substance) |
98.0-102.0% | 99.60% |
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