90566-53-3 Fluticasone Fluticasone Price
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Item |
Specification |
Result |
Appearance |
White crystalline powder |
Complies |
Related substance (HPLC) |
Total impurity ≤0.5% Max single impurity ≤0.1% |
0.2% 0.06% |
Odor |
Characteristic |
Complies |
Assay |
99% |
99.8% |
Sieve analysis |
100% pass 80 mesh |
Complies |
Loss on Drying Residue on Ignition |
≤1.0% ≤1.0% |
0.12% 0.09% |
Heavy Metal |
<10ppm |
Complies |
As |
<0.1ppm |
0.05ppm |
Pb |
<0.1ppm |
0.05ppm |
Cd |
<0.1ppm |
0.05ppm |
Residual Solvents |
<100ppm |
Complies |
Residual Pesticide |
Negative |
Complies |
Microbiology |
|
|
Total Plate Count |
<1000cfu/g |
Complies |
Yeast & Mold |
<100cfu/g |
Complies |
E.Coli |
Negative |
Complies |
"Pharmacological" this newest of glucocorticoid inhalation in the treatment of asthma. The basic structure of pregnane, activity of the molecule itself, but have powerful anti-inflammatory effects after esterification, and glucocorticoid receptors in the body with a high degree of affinity, about 18 times that of dexamethasone, Ned 3 times. The mechanism might be through the enhancement of membrane of mast cells and soluble acid stability, suppress immune responses induced by inflammation, reduce the synthesis of prostaglandins and leukotrienes.
"In vivo" this product of oral 1mg, even after 16mg,6 hours fluticasone propionate without fluorine in blood, the latter of hydrocortisone is still at a low level in the blood, indicated that oral bioavailability and urinary excretion is almost zero. After inhaling the product reached the peak serum concentration of 0.5-1.5 hours, metabolic period was extended for 5 hours, is a long-acting glucocorticoid drugs.
CAS NO:30123-17-2
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CAS NO:171596-29-5
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