cas 1342278-01-6 RKI 1447 1-(3-Hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea
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RKI-1447 is a potent Rho-associated ROCK kinase inhibitor with IC50 values of 14.5 and 6.2 nM for ROCK1 and ROCK2 respectively. It exhibits significant anti-invasive and antitumor activity in breast cancer. RKI-1447 suppresses the activation of ROCK substrates MLC-2 and MYPT1.
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