cas 64862-96-0 CI881 1,4-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione
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Ametantrone (AM) is a topoisomerase II inhibitor leading to covalent cross-links in DNA of tumor cells. It is a synthetic 9,10-anthracenedione containing two (hydroxyethylamino)ethylamino residues at positions 1 and 4. Along with other anthraquinones and anthracyclines, it shares a polycyclic intercalating moiety and charged side chains that stabilize DNA binding.
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