Pharmaceutical grade 474-25-9 intermediates/Best price

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About us

Changde Yungang Biotechnology Co., Ltd. is an export-oriented hi-tech enterprise; we are mainly engaged in the research, development, manufacturing and trade of pharmaceutical intermediates. Staring from the innovations of technology and product, Yungang is striving to develop new products and technologies; we are working hard for promoting its competitive force and sustainable developing capacity. Led by Deng Jiaguo (the founder and general manager of Yungang), we adopt the latest technologies to produce Ursodeoxycholic acid and chenodeoxycholic acid serial products. The preparation method of chenodeoxycholic acid has passed the authentication of technical achievement of our province and got several Chinese patents. At present, our Ursodeoxycholic acid can meet the standards of CP, USP and JP; Meanwhile, we also offer other specifications of products to customers with special requirements. Now, our main products including Ursodeoxycholic acid, chenodeoxycholic acid, Hyodeoxycholic acid, Cholic acid, Deoxycholic acid, Dehydrocholic acid and bacteria quarantine series such as bile salts of cow, bile salts 3, bile salts of fowl, cattle goll powder, bile powder of pig, deoxidization sodium cholate, and so on. Relying on the excellent strength of Chinese hi-tech enterprise and upholding such idea and culture spirit of "Honest, Unity, Be practical, be enterprising, be creative", we are working for customers' demands. Yungang looks forward to cooperating with you.

Chemical Properties Off-White Solid
Uses Chenodeoxycholic acid is a bile acid that induces apoptosis through protein kinase C signaling pathways.It is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion.Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.
Chenodeoxycholic acid is widely utilized in therapeutic applications. It is applied in medical therapy to dissolve gallstones. It is employed in the treatment of cerebrotendineous xanthomatosis. It is used to treat constipation and cerebrotendineous xanthomatosis. It acts as a urea receptor in supramolecular chemistry which can contain anions. It is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for dye solar cells.
Chenodeoxycholic Acid is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for Dye Solar Cells. This co-adsorbent will prevent dye aggregation on the semiconductor surface, reducing losses in the solar cell's operation.
Chenodeoxycholic Acid is a white solid added with the dye powder to the solvent while preparing staining solutions. The concentration of co-adsorbent is typically 10 fold the dye concentration.
Chenodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (CTX).
It has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies.
Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism.EC50 concentrations for activation of FXR range from 13-34 μM.In cells, CDCA also binds to bile acid binding proteins (BABP) with a reported stoichiometry of 1:2.CDCA toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess CDCA contributes to liver and intestinal cancers.

Pharmaceutical grade 474-25-9 intermediates/Best price

Quick Details

CAS No.:
474-25-9
Other Names:
Chenodeoxycholic acid powder
MF:
C24H40O4
EINECS No.:
N/M
Place of Origin:
Shaanxi, China (Mainland)
Type:
Auxiliaries and Other Medicinal Chemicals, Immune Function Agents, Vitamins, Amino Acids and Coenzymes
Grade Standard:
Medicine Grade, Tech Grade
Usage:
Animal Pharmaceuticals
Brand Name:
KONO
Model Number:
KONO3
Purity:
99%, 99%
Product Name:
Chendeoxycholic acid
Source:
bile
Appearance:
white powder
Assay by:
HPLC
Mesh size:
100% pass 80 mesh
Standard:
In house,FCC, USP/NF, JECFA, EP, GBIT
Shelf life:
2 years when properly stored
Functions:
for supplements and pharmaceuticals
Package:
drum and foil bag,or required by clients

HPLC≥98.0% 474-25-9 supplier Chenodeoxycholic Acid HPLC≥95.0%

We are the earliest factory for extraction of cdca from porcine gallbladder. Our company mainly from pig gallbladder and poultry gallbladder, extraction of pig gallbladder technology is an international initiative,  it is the core technology of our company.



Chenodeoxycholic acid Basic information
Product Name: Chenodeoxycholic acid
Synonyms: URSODEOXYCHOLOC ACID;3,7-dihydroxy-,(3-alpha,5-beta,7-alpha)-cholan-24-oicaci;3,7-dihydroxy-,(3alpha,5beta,7alpha)-cholan-24-oicaci;3,7-Dihydroxy-5-Cholanicacid;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicaci;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicacid;3-alpha,7-alpha-dihydroxycholanicacid;3-alpha,7-alpha-dihydroxycholansaeure
CAS: 474-25-9
MF: C24H40O4
MW: 392.57
EINECS: 207-481-8
Product Categories: Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Intracellular receptor
Mol File: 474-25-9.mol
Chenodeoxycholic acid Structure
Description 
Chenodeoxycholic acid (also known as chenodesoxycholic acid, chenocholic acid and 3α,7α-dihydroxy-5β-cholan-24-oic acid) is a bile acid. It occurs as a white crystalline substance insoluble in water but soluble in alcohol and acetic acid, with melting point at 165-167°C. Salts of this carboxylic acid are called chenodeoxycholates. Chenodeoxycholic acid is one of the main bile acids produced by the liver.
It was first isolated from the bile of the domestic goose, which gives it the "cheno" portion of its name (Greek: χ?ν = goose).
Chenodeoxycholic acid and cholic acid are the two primary bile acids in humans. Some other mammals have muricholic acid or deoxycholic acid rather than chenodeoxycholic acid.
Chenodeoxycholic acid is synthesized in the liver from cholesterol by a process which involves several enzymatic steps. Like other bile acids, it can be conjugated in the liver with taurine or glycine, forming taurochenodeoxycholate or glycochenodeoxycholate. Conjugation results in a lower pKa. This means the conjugated bile acids are ionized at the usual pH in the intestine and will stay in the gastrointestinal tract until reaching the ileum where most will be reabsorbed. Bile acids form micelles which facilitate lipid digestion. After absorption, they are taken up by the liver and resecreted, so undergoing an enterohepatic circulation. Unabsorbed chenodeoxycholic acid can be metabolised by bacteria in the colon to form the secondary bile acid known as lithocholic acid.
Choendeoxycholic acid is the most potent natural bile acid at stimulating the nuclear bile acid receptor, farnesoid X receptor (FXR). The transcription of many genes is activated by FXR.