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1 Kilogram	Negotiable

Min.Order :1 Kilogram
Purity: HPLC≥98.0% ；HPLC≥95.0% ；HPLC≥90.0%

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Quick Details

Appearance:White or yellowish crystallization powder, taste bitter and with unusual stink.
Application:Mainly used in the synthesis of ursodeoxycholic acid, gallstone dissolution drug. Used in gallstone disease.
PackAge:25KG/Drum
ProductionCapacity:10|Metric Ton|Month
Storage:keep in closed vessel.
Transportation:

Superiority:

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Properties

Appearance & Physical State: white to off-white crystalline powder

Density: 1.128g/cm3

Melting Point: 167-171ºC

Boiling Point: 547.1ºC at 760 mmHg

Flash Point: 298.8ºC

Refractive Index: 1.558

Water Solubility: PRACTICALLY INSOLUBLE

Storage Condition: Store in a cool, dry place. Store in a tightly closed container.

Safety Info

RTECS: FZ1980000

Safety Statements: S36/37-S45

HS Code: 2918990090

WGK Germany: 2

Risk Statements: R63

Hazard Codes: Xn

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Chenodeoxycholic acid Basic information

Product Name:	Chenodeoxycholic acid
Synonyms:	URSODEOXYCHOLOC ACID;3,7-dihydroxy-,(3-alpha,5-beta,7-alpha)-cholan-24-oicaci;3,7-dihydroxy-,(3alpha,5beta,7alpha)-cholan-24-oicaci;3,7-Dihydroxy-5-Cholanicacid;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicaci;3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicacid;3-alpha,7-alpha-dihydroxycholanicacid;3-alpha,7-alpha-dihydroxycholansaeure
CAS:	474-25-9
MF:	C24H40O4
MW:	392.57
EINECS:	207-481-8
Product Categories:	Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Intracellular receptor
Mol File:	474-25-9.mol

Description

Chenodeoxycholic acid (also known as chenodesoxycholic acid, chenocholic acid and 3α,7α-dihydroxy-5β-cholan-24-oic acid) is a bile acid. It occurs as a white crystalline substance insoluble in water but soluble in alcohol and acetic acid, with melting point at 165-167°C. Salts of this carboxylic acid are called chenodeoxycholates. Chenodeoxycholic acid is one of the main bile acids produced by the liver.

It was first isolated from the bile of the domestic goose, which gives it the "cheno" portion of its name (Greek: χ?ν = goose).

Chenodeoxycholic acid and cholic acid are the two primary bile acids in humans. Some other mammals have muricholic acid or deoxycholic acid rather than chenodeoxycholic acid.

Chenodeoxycholic acid is synthesized in the liver from cholesterol by a process which involves several enzymatic steps. Like other bile acids, it can be conjugated in the liver with taurine or glycine, forming taurochenodeoxycholate or glycochenodeoxycholate. Conjugation results in a lower pKa. This means the conjugated bile acids are ionized at the usual pH in the intestine and will stay in the gastrointestinal tract until reaching the ileum where most will be reabsorbed. Bile acids form micelles which facilitate lipid digestion. After absorption, they are taken up by the liver and resecreted, so undergoing an enterohepatic circulation. Unabsorbed chenodeoxycholic acid can be metabolised by bacteria in the colon to form the secondary bile acid known as lithocholic acid.

Choendeoxycholic acid is the most potent natural bile acid at stimulating the nuclear bile acid receptor, farnesoid X receptor (FXR). The transcription of many genes is activated by FXR.

Details:

Chenodeoxycholic acid Chemical Properties

Melting point 165-167 °C(lit.)

alpha 12 º (c=1, CHCl3)

Boiling point 437.26°C (rough estimate)

density 0.9985 (rough estimate)

refractive index 1.4460 (estimate)

Fp 9℃

storage temp. Refrigerator

solubility PRACTICALLY INSOLUBLE

form Powder

pka pKa 4.34 (Uncertain)

color White to off-white

Water Solubility PRACTICALLY INSOLUBLE

Merck 13,2062

InChIKey RUDATBOHQWOJDD-BSWAIDMHSA-N

CAS DataBase Reference 474-25-9(CAS DataBase Reference)

EPA Substance Registry System Cholan-24-oic acid, 3,7-dihydroxy-, (3.alpha.,5.beta.,7.alpha.)- (474-25-9)

Safety Information

Hazard Codes Xn

Risk Statements 63

Safety Statements 22-24/25-45-36/37

RIDADR UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany 2

RTECS FZ1980000

HS Code 29181990

Bile salts series:It is the most commonly used selective inhibitor in culture,we have Bile salts of cow ,Bile salts of pig ,Bile salts #3,Bile powder of pig

Cholic acid (Breeding)，Bile acid is a kind of functional feed additive with natural biological activity to promote fat absorption. It has been widely used in livestock and aquaculture. It can make up for the deficiency of bile acid secretion in animals and protect the liver and bile health of animals. Improving the performance of animal production,

L-2-Aminobutyric acid which is the main raw material of new antiepileptic drug levetiracetam.

About us

Changde Yungang Biotechnology Co., Ltd. is an export-oriented hi-tech enterprise; we are mainly engaged in the research, development, manufacturing and trade of pharmaceutical intermediates. Staring from the innovations of technology and product, Yungang is striving to develop new products and technologies; we are working hard for promoting its competitive force and sustainable developing capacity. Led by Deng Jiaguo (the founder and general manager of Yungang), we adopt the latest technologies to produce Ursodeoxycholic acid and chenodeoxycholic acid serial products. The preparation method of chenodeoxycholic acid has passed the authentication of technical achievement of our province and got several Chinese patents. At present, our Ursodeoxycholic acid can meet the standards of CP, USP and JP; Meanwhile, we also offer other specifications of products to customers with special requirements. Now, our main products including Ursodeoxycholic acid, chenodeoxycholic acid, Hyodeoxycholic acid, Cholic acid, Deoxycholic acid, Dehydrocholic acid and bacteria quarantine series such as bile salts of cow, bile salts 3, bile salts of fowl, cattle goll powder, bile powder of pig, deoxidization sodium cholate, and so on. Relying on the excellent strength of Chinese hi-tech enterprise and upholding such idea and culture spirit of "Honest, Unity, Be practical, be enterprising, be creative", we are working for customers' demands. Yungang looks forward to cooperating with you.