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Coluracetam 135463-81-9 Coluracetam factory
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- Appearance:white powder
- Application:pharmaceutical/pesticide intermediate
- PackAge:25kg/net drum,1kg/aluminum foil bag
- ProductionCapacity:500|Kilogram|Month
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Details:
| product name | coluracetam |
| cas no. | 135463-81-9 |
| assay | ≥99% |
| capacity | 50mt/year |
| min.packing | 1gram |
| application | pharmaceutical/pesticide intermediate |
| standard | enterprise export |
| manufacturer | kern Enterprises Co. LTD |
| more information |
synonyms: n-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide molecular formula: c19h23n3o3 molecular weight: 341.40 cas registry number: 135463-81-9 |
Product name:Coluracetam
Chemical name: N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide.
CAS:135463-81-9
Purity: 99%
Appearance: white crystalline powder
Package: 1kg/bag.
Description:
Coluracetam (BCI-540) is a nootropic drug of the racetam family.Coluracetam (formerly known as MKC-231) was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depression disorder (MDD), after being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California.Findings from its Phase 2a clinical trials have suggested that it would be an ideal medication for co-morbid MDD with generalized anxiety disorder (GAD).BrainCells Inc is currently out-licensing the drug for this purpose.It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.
Coluracetam enhances high-affinity choline uptake (HACU) which is the rate-limiting step of acetylcholine (ACh) synthesis, and is the only known choline uptake enhancer to currently exist. Studies have shown Coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects by changing the choline transporter regulation system.
| Molecular Structure |
![Molecular Structure of 135463-81-9 (1-Pyrrolidineacetamide,2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)-)](https://www.lookchem.com/300w/2010/074/135463-81-9.jpg) |
Hazard Symbols | |
| Synonyms |
Coluracetam Chemical Properties
Molecular Structure of Coluracetam (CAS No.135463-81-9):
Molecular Formula: C19H23N3O3
Molecular Weight: 341.4042
CAS No: 135463-81-9
H bond acceptors: 6
H bond donors: 1
Freely Rotating Bonds: 3
Polar Surface Area: 66.65 Å2
Index of Refraction: 1.64
Molar Refractivity: 95.35 cm3
Molar Volume: 264.3 cm3
Surface Tension: 61 dyne/cm
Density: 1.291 g/cm3
Flash Point: 337.3 °C
Enthalpy of Vaporization: 93.72 kJ/mol
Boiling Point: 634.1 °C at 760 mmHg
Vapour Pressure: 5.54E-16 mmHg at 25°C
InChI: InChI=1/C19H23N3O3/c1-11-12(2)25-19-17(11)18(13-6-3-4-7-14(13)20-19)21-15(23)10-22-9-5-8-16(22)24/h3-10H2,1-2H3,(H,20,21,23)
InChIKey: PSPGQHXMUKWNDI-UHFFFAOYAB
Std. InChI: InChI=1S/C19H23N3O3/c1-11-12(2)25-19-17(11)18(13-6-3-4-7-14(13)20-19)21-15(23)10-22-9-5-8-16(22)24/h3-10H2,1-2H3,(H,20,21,23)
Std. InChIKey: PSPGQHXMUKWNDI-UHFFFAOYSA-N
IUPAC Name: N-(2,3-dimethyl-5,6,7,8- tetrahydrofuro[2,3-b] quinolin-4-yl)-2- (2-oxopyrrolidin-1-yl)acetamide
Classification Code: Nootropic Agent
Coluracetam Uses
As a nootropic drug of the racetam family, Coluracetam may have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.
Coluracetam Specification
Coluracetam (CAS No.135463-81-9), its synonyms are N-(2,3-Dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide ; 1-Pyrrolidineacetamide, 2-oxo-N-(5,6,7,8-tetrahydro-2,3-dimethylfuro[2,3-b]quinolin-4-yl)- .
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