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Gadopentetate dimeglumine cas:86050-77-3 Gadopentetate dimeglumine 99% Gadopentetate dimeglumine
Gadopentetate dimeglumine cas:86050-77-3 Gadopentetate dimeglumine cas:86050-77-3
Gadopentetic acid is one of the trade names for a gadolinium -basedMRI contrast agent, usually administered as a salt of a complex of gadolinium with DTPA (diethylenetriaminepentacetate ) with the chemical formula A2[Gd(DTPA)(H2O)]; when cation A is the protonated form of theamino sugar meglumine the salt goes under the name "Gadopentetate dimeglumine". It was described in 1981 and introduced as the first MRI contrast agent in 1987. It is used to assist imaging of blood vessels and of inflamed or diseased tissue where the blood vessels become 'leaky'. It is often used when viewing intracranial lesions with abnormal vascularity or abnormalities in the blood–brain barrier. It is usually injected intravenously. Gd-DTPA is classed as an acyclic, ionic gadolinium contrast medium. Its paramagnetic property reduces the T1relaxation time (and to some extent the T2 and T2* relaxation times) inNMR, which is the source of its clinical utility.
CERTIFICATE OF ANALYSIS
Product |
Gadopentetate Dimeglumine |
Inspection Items |
Accepted Standard |
Results |
Appearance |
White to light yellow crystalline powder. |
White crystalline powder |
Identification |
UV λmax275nm |
Complies |
Loss on drying |
≤6.0%(1g,105℃,4hours) |
3.95% |
Analogous substance |
≤0.5% |
0.29% |
Heavy metals |
≤20ppm |
Complies |
Content of meglumine |
40.5%~42.5% |
41.6% |
Content of gadolinium |
15.1% ~18.4% |
16.7% |
Content of DTPA |
≤0.04% |
Complies |
Microbial limits |
500cfu/g |
Conforms |
Bacterial endotoxins |
<3.0Eu/mg |
Conforms |
Assay |
98.0~102.0% |
99.85% |
Conclusion :Complies to the enterprise standard |
CERTIFICATE OF ANALYSIS
Product |
Gadopentetate Dimeglumine |
Inspection Items |
Accepted Standard |
Results |
Appearance |
White to light yellow crystalline powder. |
White crystalline powder |
Identification |
UV λmax275nm |
Complies |
Loss on drying |
≤6.0%(1g,105℃,4hours) |
3.95% |
Analogous substance |
≤0.5% |
0.29% |
Heavy metals |
≤20ppm |
Complies |
Content of meglumine |
40.5%~42.5% |
41.6% |
Content of gadolinium |
15.1% ~18.4% |
16.7% |
Content of DTPA |
≤0.04% |
Complies |
Microbial limits |
500cfu/g |
Conforms |
Bacterial endotoxins |
<3.0Eu/mg |
Conforms |
Assay |
98.0~102.0% |
99.85% |
Conclusion :Complies to the enterprise standard |
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