Mechano Growth Factor PEG-MGF 2mg Per Vial best price

basic information for peg-mgf:
synonyms: peg-mgf, polyethylene glycol mechano factor
cas no.: 108174-48-7
molecular formula: c121h200n42o39
molecular weight: 2867.14
molar mass: 2888.16
peptide purity: > 98.0%
appearance: white lyophilized powder
related substance: total impurities (%) ≤ 2.0%
acetate content: ≤ 15.0%
bacterial endotoxins: ≤5 iu/mg
sequence: h-tyr-gln-pro-pro-ser-thr-asn-lys-asn-thr-lys-ser-gln-arg-arg-lys-gly-ser-thr-phe-glu-glu-his-lys-nh2
source: chemical synthesis

reconstitution: to follow best practice guidelines for reconstituting peg-mgf, reconstitute in sterile, bacteriostatic, distilled water, with light sonication if necessary.
storage for peg-mgf: vials are freeze-dried and therefore will remain stable at room temperature for 1-2 months. however, for long term storage they should be kept a 2-8 degrees celsius (refrigerator temperature), where they will remain stable for up to 18 months in powder form. once mixed with mixing solution, vials should be stored in the refrigerator and not left at room temperature.
shelf life: one year from dispatch.

mechano grow factory(mgf) is a novel splice variant of the insulin-like grow factory-1 (igf-), also known as igf-ec in humans and igf-eb in rodents. it is actually originally called mgf because the rna form of it is expressed in muscle tissues in response to the overload or/and damage of muscle growth tissue. the c-terminal peptide of the mechano grow factory (mgf) is a crucial region for the alternative splicing of the peptide. the alternative splicing in the mgf is brought about by the shift in the reading frame in which a specific c-terminal sequence (e-domain) is encoded by exon 5 and the first part of the exon 6. another interesting point in mgf is that, because of the e domain it contains, mgf can act on muscles independently from the rest of the molecule. furthermore, mgf can elicit very different effects with mgf promoting satellite cells proliferation and igf-ec inducing differentiation

how does mechano grow factory work - muscle growth!

when mechanical overload is introduced to a muscle (as by weight training), the igf- gene is released and is differentially spliced during the bodies response. initially, it it is spliced to produce predominantly igf-ec (called the mgf splice variant of igf-). this early splicing stimulates satellite cells into activation. which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. the appearance of mgf also initiates the uprgulation of new protein synthesis. after this initial splicing of igf- into mgf, production then switches towards producing a systemic release of igf-ea from the liver, which also upregulates protein synthesis as well. the expression of igf- splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary mechanism by which the body produces new muscle tissue.