CasNo.83905-01-5,Azithromycin Veterinary medicine Azithromycin,CAS no 83905-01-5,(83905-01-5) Suppliers

1 Kilogram	FOB Price: USD 15.0000

azithromycin 83905-01-5 Veterinary medicine

Product Description

Description

Azithromycin is an azalide antibiotic, which inhibits the growth of gram negative bacteria, such as Haemophilus influenza.

Azithromycin functions by interfering with 50S ribosomal subunit formation and translation, which inhibits the formation of

proteins essential for bacterial survival. Studies involving capillary electrophoresis suggest that Azithromycin can be used as a

chiral selector for enantiomeric separation of compounds. In addition, Azithrmycin can be used to increase chloride efflux and

selectively reduces tumor necrosis factor α in human cystic fibrosis cells. Furthermore, Azithromycin reduces LPS-induced

pulmonary neutrophilia in mice, via suppressing the expression of IL-1β.

Specification

Items	Specifications	Results
Appearance	White or almost white powder	White powder
Solubility	Practically insoluble in water, freely soluble in anhydrous ethanol and in methylene chloride	Conforms
Idetification	1) IR: Conforms to the spectrum of Azithromycin RS	Conforms
Idetification	2) HPLC: The retention time of azithromycin peak in the chromatogram of the assay preparation corresponds to that in the chromatogram of the Standard preparation, as ovtained in the assay	Conforms
Specific rotation	-45°~ -49°	-47°
Crystallinity	Meets the requirements	Conforms
pH	9.0~11.0 (2mg/ml methanol-water(1:1))	10.1
Water	4.0%~5.0%	4.60%
Residue on ignition	≤0.3%	0.01%
Heavy metals	≤25ppm	<25ppm
	Impurity A ≤0.5%	Not detected
	Impurity B ≤1.0%	0.40%
	Impurity C ≤0.5%	0.22%
	Impurity J ≤0.3%	0.11%
	Impurity E ≤0.5%	Not detected
	Impurity F ≤0.5%	<0.10%
	Impurity G ≤0.5%	Not detected
Related Substances(HPLC Test 2)	Impurity I ≤0.7%	Not detected
	Impurity L≤0.5%	Not detected
	Impurity M≤0.5%	Not detected
	Impurity N ≤0.5%	Not detected
	Impurity O≤0.5%	0.11%
	Impurity P ≤0.2%	<0.10%
	Any other impuirty ≤0.2%	<0.10%
	Total impurities ≤3.0%	0.84%
Residual Solvents	Methylene Chlorde≤600ppm	Not detected
Residual Solvents	Acetone ≤5000ppm	330ppm
Assay	945~1030μg/mg (Anhydrous substance )	978μg/mg
Conclusion	The results can conforms with the USP37 standard.