CasNo.103-90-2,paracetamol CAS 103-90-2,(103-90-2) Suppliers

25 Kilogram	FOB Price: USD 5.0000

Min.Order :25 Kilogram
Purity: 99%
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Keywords

paracetamol 103-90-2 paracetamol powder

Quick Details

Appearance:fine powder
Application:health supplement
PackAge:1kg/bag, 25kg/drum
ProductionCapacity:10|Metric Ton|Day
Storage:cool, dry place and avoid strongl light
Transportation:DHL,TNT,FEDEX,EMS, by air, by sea

Superiority:

paracetamol

roduct Name:	Acetaminophen
Synonyms:	PARACETAMOL BP2001;PARACETAMOL POWDER;PARACETAMOL POWDER BP;PARACETAMOL BP;ACETAMINOPHENOL POWDER PB/USP;PARACETAMOL DC GRADE;PARACETAMOL BP98;PARACETAMOL USP23,BP98
CAS:	103-90-2
MF:	C8H9NO2
MW:	151.16
EINECS:	203-157-5
Product Categories:	Aromatics;Intermediates & Fine Chemicals;PHARMACEUTICALS;Aromatic Phenols;Lipid signaling;DMF file is ok to be provided.;inhibitor;APIs;Pyridines;103-90-2;1
Mol File:	103-90-2.mol

Acetaminophen Chemical Properties

Melting point	168-172 °C(lit.)
Boiling point	273.17°C (rough estimate)
density	1,293 g/cm³
vapor pressure	0.008Pa at 25℃
refractive index	1.5810 (rough estimate)
Fp	11 °C
storage temp.	Inert atmosphere,Room Temperature
solubility	ethanol: soluble0.5M, clear, colorless
pka	9.86±0.13(Predicted)
form	Crystals or Crystalline Powder
color	White
PH	5.5-6.5 (H2O, 20℃)(saturated solution)
PH Range	5.5 - 6.5 (H O, 20 °C) (saturated solution)
explosive limit	15%(V)
Water Solubility	14 g/L (20 ºC)
Merck	14,47
BRN	2208089
InChIKey	RZVAJINKPMORJF-UHFFFAOYSA-N
LogP	1.098 at 25℃
CAS DataBase Reference	103-90-2(CAS DataBase Reference)
NIST Chemistry Reference	Acetaminophen(103-90-2)
IARC	3 (Vol. 50, 73) 1999
EPA Substance Registry System	Acetaminophen (103-90-2)

Safety Information

Hazard Codes	Xn,T,F
Risk Statements	22-36/37/38-52/53-36/38-40-39/23/24/25-23/24/25-11
Safety Statements	26-36-61-37/39-22-45-36/37-16-7
RIDADR	UN 3077 9/PG III
WGK Germany	1
RTECS	AE4200000
Autoignition Temperature	540 °C
TSCA	Yes
HazardClass	9
PackingGroup	III
HS Code	29242930
Hazardous Substances Data	103-90-2(Hazardous Substances Data)
Toxicity	LD50 in mice (mg/kg): 338 orally (Starmer), 500 i.p. (Dahlin, Nelson)

Details:

paracetamol

Usage and Dosage

Usage
This product is antipyretic and analgesic whose international nonproprietary name is Paracetamol. It is the most common non anti-inflammatory analgesia-antipyretic drugs without anti inflammatory and anti rheumatism action. Its antipyretic effect is similar to aspirin, but analgesic effect is weak. It is the best of breed of acetanilid drugs. The product is especially suitable for patients who cannot use carboxylic acids drugs. It is used for cold and toothache. Acetaminophen is also used as organic synthesis intermediates, stabilizer of hydrogen peroxide, photographic chemicals.
Dosage
1. Oral (1) Paracetamol tablets or paracetamol capsules: adults take 300～600mg at a time and 3～4 times a day according to the need. The daily dosage should not be greater than 2g. Defervescence treatment is generally less than 3 days and the administration of pain relief lasts less than 10 days. Children take 10～15mg/kg every 4～ 6 hours. The dosage of children under the age of 12 does not exceed 5 times a day, a five-day course at most. This product should not be taken for a long time.
2. Dispersible tablets: When take tablets, disperse them in warm water dispersion. The commonly used amount of children is 10～15mg/kg every 4～ 6 hours. The dosage of children under the age of 12 does not exceed 5 times a day, a five-day course at most. Children under 3 years old cut back on the amount.

Application in Particular Diseases

In Osteoarthritis：

Acetaminophen is recommended by the ACR as first-line drug therapy for pain management of OA. The dose is 325 to 650 mg every 4 to 6 hours on a scheduled basis (maximum dose 4 g/day; maximum 2 g/day if chronic alcohol intake or underlying liver disease). Comparable relief of mild to moderate OA pain has been demonstrated for acetaminophen (2.6 to 4 g/ day) compared with aspirin (650 mg four times daily), ibuprofen (1,200 or 2,400 mg daily), and naproxen (750 mg daily). However, some patients respond better to NSAIDs.
Acetaminophen is usually well tolerated, but potentially fatal hepatotoxicity with overdose is well documented. It should be used with caution in patients with liver disease and those who chronically abuse alcohol. Chronic alcohol users (three or more drinks daily) should be warned about an increased risk of liver damage or GI bleeding with acetaminophen. Other individuals do not appear to be at increased risk for GI bleeding. Renal toxicity occurs less frequently than with NSAIDs.