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Active Pharmaceutical Ingredients CAS 73963-72-1 Cilostazol

Active Pharmaceutical Ingredients CAS 73963-72-1 Cilostazol

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100 Gram

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  • Min.Order :100 Gram
  • Purity: 99%
  • Payment Terms : T/T,

Keywords

73963-72-1 Cilostazol C20H27N5O2

Quick Details

  • Appearance:White crystal powder
  • Application:Pharmaceutical Raw Material
  • PackAge:100g/ bag, 2 kg/ bag, 25kg/ carton or as required
  • ProductionCapacity:20000|Kilogram|Day
  • Storage:Store in sealed containers at cool & dry place. Protect from light, moisture and pest infestation.
  • Transportation:By DHL, TNT, FedEx, HKEMS, UPS, Etc

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		Active Pharmaceutical Ingredients CAS 73963-72-1 Cilostazol 

	

		

			 

		

			Quick Details 

			Product Name: Cilostazol

			Synonyms: 6-[4-(1-CYCLOHEXYL-1H-TETRAZOL-5-YL)BUTOXY]-3,4-DIHYDRO-2(1H)-QUINOLINONE;6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1h)-quinolinone additional name: 6-[4-(1-cyclohexyl-5-tetrazolyl)butoxy]-1,2,3,4- tetrahydro-2-oxoquinolinone;CILASTAZOL;CILOSTAZOL;CILOSTAZOLE;RETAL;OPC 13013;OPC 21

			CAS: 73963-72-1

			MF: C20H27N5O2

			MW: 369.46

			Product Categories: Active Pharmaceutical Ingredients;Intermediates & Fine Chemicals;Pharmaceuticals;API's;inhibitor;Cardiovascular APIs

			Melting point  159-160°C

			Storage temp.  Store at RT

			Chemical Properties : White crystalline powders

			Usage : antibacterial; LD50(iv) 280mg/kg(mouse) 

			Usage : A potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo .

			

			 

		

			
				

					
						Pharmacological effects
				

			
		

		

		Cilostazol is commonly used clinically anti-platelet and anti-clotting drugs. It belongs to a phosphodiesterase inhibitor and can inhibit the activity of phosphodiesterase of platelet and smooth muscle cells, leading to increase of the cAMP concentration in platelets and vascular smooth muscle. It can significantly inhibit the platelet aggregation induced by various kinds of aggregation inducers, and can cause the dissociation of the aggregates. Its major metabolite, epoxide has a three to four fold activity of the prototype drug. It has significant antithrombotic effect on the brain circulation and peripheral circulatory disturbance caused by collagen, ADP, arachidonic acid and sodium laurate. Artery injection of this product can increase the blood flow rate with the strongest effect on the peripheral blood vessels but the weakest effect on the cerebral blood vessels. 

		

		This product is rapidly absorbed in the intestine after oral administration with the Tmax being 3h, PPB being about 95%. Consecutive administration of four days by twice per day caused no increase in the plasma concentration accumulation. It has good tissue distribution with especially high level in the stomach, liver and kidney. At 72h after administration, 42.75% of the administered drug is excreted via urine and 61.7% is subject to fecal excretion. After 48 hour of administration, bile excretion rate is 31.7%. T1 / 2α is 2.2h and T1 / 2β is 18h.  

		

		

		

			
				

					
						Cilostazol Clinical Application
				

			
		

		

		It can be used to alleviate the ischemic symptom such as ulcers, limb pain, cold sensation and intermittent claudication caused by chronic arterial occlusive disease. It can also be applied to the adjuvant treatment of atherosclerosis, arteritis, thromboangiitis obliterans, diabetes-induced ischemia of extremity and takayasu arteritis. Cilostazol also be used as a complementary therapy after surgical treatment to help alleviate the symptoms, improve the circulation and inhibiting thrombosis in transplanted blood vessel . 

		

		 
		

			
				

					
						Cilostazol Uses 
				

			
		

		

			

			It can significantly inhibit the platelet aggregation caused by various inducers and aggregates and can dissociate the aggregates without causing secondary aggregation. It has significant antithrombotic effect on the brain circulation and peripheral circulatory disturbance caused by collagen, ADP, arachidonic acid and sodium laurate. It can also be used for treating ischemic diseases such as chronic arterial occlusive ulcer, pain and coldness . 

	





	 



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	Hubei XinRunde Chemical Co., Ltd is a renowned pharmaceutical manufacturer. We can offer high quality products at competitive price in quick delivery with 100% custom pass guaranteed. Never stop striving to offer our best service is our philosophy. We have Flexible and Untraceable payment terms. As a leading manufacture, our products have been exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Brazil, Mexico, Australia, Japan, Korea, Thailand, Indonesia, Uruguay and many other countries.



	

	1. Quality.Every batch of steroid powders have tobetested by our QC(quality control) before they are allowed to sell.



	

	2 . Delivery We have stock, so we can delivery quickly at the very day when receive the payment. Within 24 hours after receiving the payment Lead time 4 or 7 days.



	

	3 . Discreet package Safelyand Professionally Disguised Package Guaranteed. For your safety and to insure delivery all products will be packed in a discreet way to prevent any suspicions, no steroids related name will appear on the parcels. high successful delivery rate

	

	4 . Warm after-sale service Any of your question would be solved for the first as soon as possible.



	 



	

		 





	Active Pharmaceutical Ingredients CAS 73963-72-1 Cilostazol 



                        

                

                

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