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288383-20-0 Cediranib AZD2171
Name: cediranib
CAS NO. 288383-20-0
Chinese alias 4-(4-fluoro-2-methylindole-5-oxy) -6-methoxy-7-[3-(pyrrolidine-1-yl) propoxy] quinazoline
English name Cediranib
Molecular formula C25H27FN4O3
Molecular weight 450.51
Density: 1.286g/cm
Flash point: 332.73 degree C
Steam pressure: 0mmHg at 25 degree C
Si Di Knibb (Cediranib) is also called AZD2171, the trade name recentin.
Pharmacological action: Cidinib is a tyrosine kinase inhibitor of pan-vascular endothelial growth factor (pan-VEGF) receptor. It mainly inhibits VEGFR-1, VEGFR-2, VEGFR-3 and PDGFR. Sildenib can inhibit three kinds of vascular endothelial growth factor (VEGF) receptors, act on blood vessels and lymphatics, and play an anti-angiogenesis role.
Physical properties: yellowish powder. It is soluble in methanol, ethyl acetate and dichloromethane, and is insoluble in water. The solubility in DMSO is 10mmol/L.
Storage conditions: -20 degrees Celsius, avoiding light, moisture proof, closed and dry.
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