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Top quality of  exporter 14636-12-5 Competitive price of Terlipressin

Top quality of exporter 14636-12-5 Competitive price of Terlipressin

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1 Gram

FOB Price: USD 1.0000

  • Min.Order :1 Gram
  • Purity: 99%
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Terlipressin exporter Competitive price of Terlipressin Top quality of 14636-12-5

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  • Appearance:WHITE POWDER
  • Application:PEPTIDE
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  • ProductionCapacity:1|Kilogram|Day
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Top quality of  exporter 14636-12-5 Competitive price of Terlipressin

N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin Basic information
Pharmacological effects Mechanism of Action Adverse Drug Reactions

 

Product Name:

N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin
Synonyms: Triglycyl-8-lysine-vasopressin;H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2;TerlipressinuM;Terlipressin Diacetate Salt;Terlipressin acetate, >=98%;Thymosin al Acetate;TERLIPRESSIN;TERLIPRESSIN ACETATE
CAS: 14636-12-5
MF: C52H74N16O15S2
MW: 1227.37
EINECS: 238-680-8
Product Categories: hormones;Amino Acid Derivatives;Peptide
Mol File: 14636-12-5.mol
N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin Structure

About us:

 
Zhejiang Sa-chen pharmaceutical technology company is a subsidiary of Heze Pharma. Which is committed to import and export of Hormone and steroid API and intermediates, Pharmaceutical Raw material and intermediates and APIs registration since the foundation.
 
Company possessed a professional marketing team, with the support of several GMP factories partners’ assistant, company build a strategy partnership with the GMP factories which located in Zhejiang, Hunan, Jiangsu provinces, which make us own the reputation all over the world.
 
Our head company Heze Pharma is a MAH (Marketing Authorization Holder) enterprise which is seeking to the cooperation with foreign GMP factory for the API registration in China, to achieving Mutual Benefit and Common Development. With decade of professional experience in API and formulation registration, Heze Pharma is familiar with related regulatory.
Heze possessed a professional registration team, which can assistant customers for the API registration in China with the DMF audit, translation and application process. We can work as a sole agent for the API registration and sales, to assist customers for the API registration in China, or we can work as agent of registration, assist customers for the API registration.

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Top quality of  exporter 14636-12-5 Competitive price of Terlipressin

Pharmacological effects Terlipressin is a novel long-acting synthetic vasopressin reagent,its chemical name is three glycyl lysine vasopressin, it is a prodrug, itself has no activity ,in vivo  , it removes three glycyl residues in its N-terminus by aminopeptidase, and slowly "releases" the active lysine vasopressin. It is this "slow release" mechanism that makes it maintain the smooth muscle contraction up to 10 hours after a single administration, whereas the same dose of vasopressin, it can maintain its activity for 20-40 minutes. On the other hand,because of the slow digestion,  lysine vasopressin in the circulation cannot reach toxic levels, and usage of  terlipressin is safer.

Pharmacological effect of terlipressin is splanchnic vascular smooth muscle contraction, and reduction of visceral blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal vein blood flow,and reducing portal pressure, on the other hand it may also reduce plasma renin concentration, thereby increasing the renal blood flow in patients with hepatorenal syndrome, to improve kidney function, and increase urine output. Terlipressin is currently the only drug which is able to increase mortality in patients with esophageal varices bleeding , it is previously mainly used in clinical for the treatment of variceal bleeding, in addition,terlipressin now has also been successfully used for liver and kidney integrated syndrome and refractory shock, it is also likely to play a useful role in the cardiopulmonary resuscitation . Compared with vasopressin, it has a lasting effect, and it does not cause dangerous complications, including promoting  fibrinolysis and severe complications in the cardiovascular systems, and the use of it is simple (available intravenous injection), it is more suitable for rescue and treatment of emergent and critical  patients.
Mechanism of Action Terlipressin, a synthetic triglycyl-lysine derivative of vasopressin, is a inactive prodrug. It has pressor and antidiuretic effects. Following IV injection, lysine vasopressin are released following the enzymatic cleavage of 3 glycyl moieties.
Duration: 4-6 hr.

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