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100 Gram |
Negotiable |
50700-72-6 Vecuronium bromide C34H57BrN2O4
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Description
Vecuronium Bromide competes with acetylcholine and binds to cholinergic receptors at neuromuscular junctions.
Vecuronium bromide is a drug which can be supplied to general anesthesia to keep skeletal muscle relaxation during the surgery or mechanical ventilation. It can also be used to help with endotracheal intubation. It has rapid onset (within 4 minutes) and has its effect last for 4 hour. Its mechanism of action is through competitively binding to the nicotinic cholinergic receptors, further antagonizing the opportunity for acetylcholine from binding to the nicotinic receptor at the postjunctional membrane of the myoneural junction. This process prevents the depolarization and the release of calcium ions, stopping muscle contraction and help muscle relaxation.
Specification
ITEMS |
SPECIFICAITONS |
RESULTS |
Appearance |
White, yellowish-white or slightly pink crystalline powder |
White crystalline powder |
Solubility |
------- |
Complies |
Identification |
1) The IR absorption spectrum of the sample is concordant with that of Pancuronium Bromide standard 2) It gives reaction of bromides |
Positive |
Specific optical rotation |
+38.0°~+42° |
+41.2° |
Appearance of solution |
Clear and colourless |
Complies |
Related Substances (TLC) |
Impurity A NMT 1.0% Impurity D NMT 1.0% any other impurities NMT 0.1% |
Complies |
Water |
NMT8.0% |
3.5% |
Sulphated ash |
NMT0.1% |
0.09% |
Assay |
98.0~102.0% |
99.7% |
Conclusion: It conforms to the EP STANDARD. |
Advantages:
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