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99% Dasatinib 99% Dasatinib 99% Dasatinib
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CML Treatment Dasatinib Powder Active Pharmaceutical Ingredient CAS 302962-49-8
Introduction
Dasatinib, previously known as BMS-354825, is a cancer drug produced by Bristol-Myers Squibb and sold under the trade name Sprycel. Dasatinib is an oral Bcr-Abl tyrosine kinase inhibitor (inhibits the "Philadelphia chromosome") and Src family tyrosine kinase inhibitor approved for first line use in patients with chronic myelogenous leukemia (CML)[1] and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). It is being evaluated for use in numerous other cancers, including advanced prostate cancer.
Efficacy
In a Phase I dose escalation study published in June 2006, dasatinib was tested in patients who were resistant to or who could not tolerate imatinib.[2] Complete hematological responses[3] were seen in 37 of 40 patients with chronic-phase CML. Major hematologic responses were seen in 31 of 44 patients with accelerated-phase CML, CML in blast crisis, or Ph+ ALL.
Medical Uses
Oxaliplatin is used for treatment of colorectal cancer, typically along with folinic acid and 5-fluorouracil in a combination known as FOLFOX. Oxaliplatin has been compared with other platinum compounds used for advanced cancers, such as cisplatin and carboplatin.
Product Name | Dasatinib monohydrate | ||
Appearance | White to off- white crystalline powder | ||
Odor &Taste | Characteristic | ||
Test Method | HPLC | ||
Specification | 98.5%min | ||
Supplier | vanz | ||
CAS# | 863127-77-9 | ||
Molecular Formula | C22H26ClN7O2S.H2O | ||
Molecular Weight | 506.02 | ||
Structure |
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Packing | |||
N.W.25kgs G.W.28kgs Paper-drums and two plastic-bags inside. |
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Storage | |||
Store in cool & dry place.Keep away from strong light and heat. | |||
Shelf life | |||
24 months when properly stored. |
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