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Pharmaceutical Raw Materials Anti Diabetes Drug Empagliflozin Manufacturer 864070-44-0

Pharmaceutical Raw Materials Anti Diabetes Drug Empagliflozin Manufacturer 864070-44-0

Min.Order / FOB Price:Get Latest Price

0 Gram

Negotiable

  • Min.Order :0 Gram
  • Purity: 99%
  • Payment Terms : L/C

Keywords

99% Empagliflozin 99% Empagliflozin 99% Empagliflozin

Quick Details

  • Appearance:white crystalline powder
  • Application:use in chemical
  • PackAge:bags
  • ProductionCapacity:12|Kilogram|Day
  • Storage:Kept in a well-closed, light-resistant,dry and cool place
  • Transportation:by sea or express

Superiority:

1. Rich experience.
Our company is a professional production leading factory in China in pharmaceutical area of many years, our products have exported to Germany, Spain, UK, USA, Australia, Middle East, and so on other country, and we have got very good feedback from our customers, we had Established long friendly relations of cooperation. High quality, best price!
2. Great quality, purity and favourable.
Good quality is one of our secret success, welcome order the samples, MOQ just 10 grams.
3. Safe and fast delivery.
We have warehouse in Australia, Canada and England, we have large amounts of stock in the warehouse, can ship to you directly from our foreign warehouse! So we can delivery quickly at the very day when receive the payment. And We offer melting powder into liquid service.
4. Good after-sales service.

 

Details:

 

Empagliflozin Description

Empagliflozin (trade name Jardiance) is a drug of the gliflozin class, approved for the treatment of type 2 diabetes in adults in 2014. It was developed by Boehringer Ingelheim and Eli Lilly and Company.


Empagliflozin is an inhibitor of the sodium glucose co-transporter-2 (SGLT-2), and causes sugar in the blood to be excreted by the kidneys and eliminated in urine.


Empagliflozin is a potent SGLT-2 inhibitor and has a high degree of selectivity over SGLT-1, 4, 5 and 6 than other reported SGLT-2 inhibitors. When tested with a panel of human cell lines over-expressed SGLT-1, 2, 4, 5 and 6,

Empagliflozin treatment competitively bind to SGLT-2 over glucose at low dose .


In human proximal tublular cell (PTC) cell line HK2 cells, Empagliflozin treatment for 72 h inhibits the expression of SGLT-2 which in turn reversed high glucose induced TLR4 expression, NF-κB binding, IL-6 secretion, AP-1 binding and CIV expression .


Empagliflozin Basic Information

Name Empagliflozin
Synonyms BI 10773; (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucitol
Molecular Formula C23H27ClO7
Molecular Weight 450.91
CAS Registry Number 864070-44-0
 
 

 

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