API Tenofovir CAS 1...

API Tenofovir CAS 147127-20-6 For Anti-HIV Pharma Raw Materials

API Tenofovir CAS 147127-20-6 For Anti-HIV Pharma Raw Materials

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10 Gram

FOB Price:USD 1.0000 -2.0000
  • Min.Order :10 Gram
  • Purity: 99%
  • Payment Terms : L/C

Keywords

147127-20-6 147127-20-6 147127-20-6

Quick Details

  • Appearance:white crystalline powder
  • Application:use in chemical
  • PackAge:bags
  • ProductionCapacity:12|Kilogram|Day
  • Storage:Kept in a well-closed, light-resistant,dry and cool place
  • Transportation:by sea or express

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Details:

API Tenofovir CAS 147127-20-6 For Anti-HIV Pharma Raw Materials

 

Tenofovir


CAS: 147127-20-6
MF: C9H14N5O4P
MW: 287.21
mp 276-280°C
storage temp. Store at -20°C
Water Solubility 13.4 mg/mL (25 oC)
Chemical Properties White Crystalline Solid
Usage Acyclic phosphonate nucleotide analogue. Used as an anti-HIV agent
Usage Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
Purity: 99%
Usage: API
Package: 1KG foil bag; 25Kg drum

 

Tenofovir Usage And Synthesis

 

1. Antiviral drugs, Tenofovir is an acyclic nucleoside antiviral reverse transcriptase inhibitor. The active substance is Tenofovir disoproxil, while tenofovir is a prodrug that is used because of its better absorption in the gut.

 

2. Tenofovir can inhibit viral polymerase through direct competitively combine with natural deoxyribose or by insertion to terminate chain of human DNA. It is the first nucleotide analogs to treat HIV-1 infection that approved by the US Food and Drug Administration (FDA).

 

3. Tenofovir is a main medicine in AIDS cocktail therapy, researches has shown that it can effectively improve the monkeys` ability on prevention of immunodeficiency virus (similar to the human AIDS virus).

 

COA

 

Items of analysis

Specification

Results

Appearance

White powder or off-white powder

White Powder

Identification

Must conform to reference standard

Conforms

Water

NMT3.0%

1.53%

Residue on ignition

NMT2.0%

1.07%

Specific Rotation

-19.0°~-23.0°

-22.5°

Sulphated ash

≤1.5%

0.27%

Single impurity

≤1.0%

0.29%

Total impurity

≤3.0%

1.11%

Assay(Titrimetry)

98.0%-102%

98.60%

9-Propenyl adenine

≤100ppm

Conforms

PMPA Monoester Impurity

≤1.5%

0.35%

Conclusion

Qualified

 

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