Strong 99% Anticonv...

Strong 99% Anticonvulsant Active Pharmaceutical Ingredients Topiramate CAS 97240-79-4

Strong 99% Anticonvulsant Active Pharmaceutical Ingredients Topiramate CAS 97240-79-4

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10 Gram

FOB Price:USD 1.0000 -2.0000
  • Min.Order :10 Gram
  • Purity: 99%
  • Payment Terms : L/C

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97240-79-4 97240-79-4 97240-79-4

Quick Details

  • Appearance:white crystalline powder
  • Application:use in chemical
  • PackAge:bags
  • ProductionCapacity:12|Kilogram|Day
  • Storage:Kept in a well-closed, light-resistant,dry and cool place
  • Transportation:by sea or express

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Details:

Strong 99% Anticonvulsant Active Pharmaceutical Ingredients Topiramate CAS 97240-79-4

 

Topiramate-----------Quick Details

 

Topiramate Product Name: Topiramate
Topiramate CAS: 97240-79-4
Topiramate MF: C12H21NO8S
Topiramate MW: 339.36
Topiramate EINECS: 200-659-6
Topiramate Product Categories: Active Pharmaceutical Ingredients;APIs;Health & Beauty;Carbohydrates & Derivatives;Pharmaceuticals;Glutamate receptor;Intermediates & Fine Chemicals;API;TOPAMAX;Pharmaceutical raw materials
Topiramate Melting point : 125°C
Topiramate Storage temp. : 2-8°C
Topiramate Chemical Properties : White-to-Off-White Crystalline Powder
Topiramate Usage : anticonvulsant, antimigraine, GABA-A agonist, AMP/kinate glutamate receptor antagonist, carbonic anhydrase inhibitor

 

Topiramate-----------Description

 

Topiramate (brand name Topamax) is an anticonvulsant (antiepilepsy) drug. In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for weight loss. The drug had previously been used off-label for this purpose.

 

Topiramate was originally produced by Ortho-McNeil Neurologics and Noramco, Inc., both divisions of the Johnson & Johnson Corporation. This medication was discovered in 1979 by Bruce E. Maryanoff and Joseph F. Gardocki during their research work at McNeil Pharmaceutical.

 

Topiramate COA

 

Items

Specifications

 Results
Appearance White to off-white powder, Freely soluble in dichloromethane White powder, Freely soluble in dichloromethane
Identification Infared Absorption Complies
The retention time of the major peak in the chromatogram of the Assay prepration corresponds to that in the chromatogram of the standard preparation, as obtained in the assay complies
Specific rotation Between -28.6°and -35.0°, measured at 20° -32.8°
Water not more than 0.5% 0.12%
residue on ignition not more than 0.2% 0.11%
Heavy metals not more than 0.001% complies
related compounds by HPLC(Test1) Fructose not more than 0.3% Compound A not more than 0.3% Other individual impurity not more than 0.1% Total impurities not more than 0.5% Fructose: 0.03%
Compound A:0.04%individual impurity Total impurities: 0.07%
Particle size 90% less than 350 microns complies
Limit of sulfamate and sulfate Sulfamate ion not more than 0.10% Sulfate ion not more than 0.10% complies
Residual Solvent Methylene Chloride not more than 250μg/g not detected
Acetone not mor than 2500μg/g
Isopropanol not more than 5000μg/g
Ethanenitrile not more than 400μg/g
n-hexane not more than 290μg/g
Ethyl Acetate not more than 2500μg/g
Pyridine not more than 100μg/g
Assay Topiramate contains not less than 98.0% and not more than the equivalent of 102.0% of C12H21NO8S, calculated with reference to the Anhydrous Basis 99.80%
Conclustion The material complies with respect to USP35

 

Topiramate Medical uses

 

Topiramate is used to treat epilepsy in children and adults, and it was originally used as an anticonvulsant. In children, it is indicated for the treatment of Lennox-Gastaut syndrome, a disorder that causes seizures and developmental delay.

 

Topiramate is also Food and Drug Administration (FDA) approved for, and most frequently prescribed for, the prevention of migraines. The drug is also used to treat migraines due to the effect it has on the blood vessels in the brain. It has been found to be increasingly effective for migraine sufferers with limited side effects .

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