Venlafaxine Hydroch...

Venlafaxine Hydrochloride Controls Depression Hot Flashes Drugs CAS 99300-78-4 Powder

Venlafaxine Hydrochloride Controls Depression Hot Flashes Drugs CAS 99300-78-4 Powder

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10 Gram

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99300-78-4 99300-78-4 99300-78-4

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  • Appearance:white crystalline powder
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Details:

Venlafaxine Hydrochloride Controls Depression Hot Flashes Drugs CAS 99300-78-4 Powder

Quick detail

venlafaxine hydrochloride
CAS No.: 99300-78-4
Synonyms:

Venlafaxine Hydrochloride; Venlafaxine hydrochloride;
Formula: C17H28ClNO2
Exact Mass: 313.18100
Molecular Weight: 313.86300
PSA: 32.70000
LogP: 3.83760
Appearance & Physical State: white crystalline powder
Density: 1.394 g/cm3
Melting Point: 207-209ºC
Boiling Point: 397.6ºC at 760 mmHg
Flash Point: 194.2ºC


Venlafaxine Description

Venlafaxine is a widely used serotonin- and norepinephrine-reuptake inhibitor-type antidepressant that causes serious adverse effects in at least 5% of cases. Serious withdrawal symptoms may occur within hours of cessation or reduction of the usual dosage and may affect motor and coordination skills to such a degree that patients should be explicitly urged either to adhere to a strict medication routine or not to drive a car. Recent clinical evidence about withdrawal symptoms is presented that may indicate incidents in noradrenergic activity irrespective of dosage.

 

Venlafaxine Usage

1 Major Depressive Disorder
2 Generalized Anxiety Disorder
3 Social Anxiety Disorder (Social Phobia)
4 Panic Disorder
5 Patients With Hepatic Impairment
6 Patients With Renal Impairment
7 Maintenance Treatment

 

DOSAGE AND ADMINISTRATION

1 Major Depressive Disorder For most patients, the recommended starting dose for Effexor XR is 75 mg per day, administered in a single dose. For some patients, it may be desirable to start at 37.5 mg per day for 4 to 7 days to allow new patients to adjust to the medication before increasing to 75 mg per day. Patients not responding to the initial 75 mg per day dose may benefit from dose increases to a maximum of 225 mg per day. Dose increases should be in increments of up to 75 mg per day, as needed, and should be made at intervals of not less than 4 days, since steady-state plasma levels of venlafaxine and its major metabolites are achieved in most patients by day 4
2 Generalized Anxiety Disorder For most patients, the recommended starting dose for Effexor XR is 75 mg per day, administered in a single dose. For some patients, it may be desirable to start at 37.5 mg per day for 4 to 7 days to allow new patients to adjust to the medication before increasing to 75 mg per day. Patients not responding to the initial 75 mg per day dose may benefit from dose increases to a maximum of 225 mg per day. Dose increases should be in increments of up to 75 mg per day, as needed, and should be made at intervals of not less than 4 days, since steady-state plasma levels of venlafaxine and its major metabolites are achieved in most patients by day 4
3 Social Anxiety Disorder (Social Phobia) The recommended dose is 75 mg per day, administered in a single dose. There was no evidence that higher doses confer any additional benefit.
4 Panic Disorder The recommended starting dose is 37.5 mg per day of Effexor XR for 7 days. Patients not responding to 75 mg per day may benefit from dose increases to a maximum of approximately 225 mg per day. Dose increases should be in increments of up to 75 mg per day, as needed, and should be made at intervals of not less than 7 days.
5 Patients With Hepatic Impairment The total daily dose should be reduced by 50% in patients with mild (Child-Pugh=5-6) to moderate (Child-Pugh=7-9) hepatic impairment. In patients with severe hepatic impairment (Child-Pugh=10-15) or hepatic cirrhosis, it may be necessary to reduce the dose by 50% or more
6 Patients With Renal Impairment The total daily dose should be reduced by 25% to 50% in patients with mild (CLcr= 60-89 mL/min) or moderate (CLcr= 30-59 mL/min) renal impairment. In patients undergoing hemodialysis or with severe renal impairment (CLcr < 30 mL/min), the total daily dose should be reduced by 50% or more. Because there was much individual variability in clearance between patients with renal impairment, individualization of dosage may be desirable in some patients
7 Maintenance Treatment

There is no body of evidence available from controlled studies to indicate how long patients with MDD, GAD, SAD, or PD should be treated with Effexor XR.

It is generally agreed that acute episodes of MDD require several months or longer of sustained pharmacological therapy beyond response to the acute episode. Effexor XR/Effexor have demonstrated continuation of response in clinical studies up to 52 weeks, at the same dose at which patients responded during the initial treatment

 

Precautions Use cautiously in


• cardiovascular disease; hypertension; heart failure, recent myocardial infarction, and other conditions in which increasedheart rate poses a danger; hepatic or renal impairment; glaucoma; hyperthyroidism; hyponatremia; syndrome ofinappropriate antidiuretic hormone secretion (SIADH)
• history of seizures, neurologic impairment, or drug abuse
• pregnant or breastfeeding patients
• children younger than age 18.

 

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